2023年中国肝移植基础研究年度盘点  

Summary of basic research on liver transplantation in China of 2023

作　　者：叶晓勇 周林 贺强[1] Ye Xiaoyong;Zhou Lin;He Qiang(Department of Hepatobiliary Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院肝胆外科,北京100020

出　　处：《器官移植》2024年第3期367-376,共10页Organ Transplantation

基　　金：国家自然科学基金(82370665);北京市自然科学基金(7212042、7222303、7232068);北京朝阳医院金种子科研基金(CYJZ202204)。

摘　　要：肝移植是终末期肝病和肝细胞癌的最佳治疗手段,可显著改善患者预后,提高患者生存质量。但排斥反应、免疫耐受、供肝短缺、供肝保存、缺血-再灌注损伤、术后并发症等诸多重难点,限制了肝移植在临床中的应用效果。我国科研团队不断努力,结合新兴技术、多学科交叉等新兴领域的发展,对肝移植相关基础研究做出了巨大贡献。本文就2023年度肝移植基础研究相关的前沿进展进行综述,重点关注中国团队在肝移植基础研究领域取得的进展,以期为促进中国特色融入肝移植领域研究中,加快中国肝移植研究事业和国际接轨,推动我国肝移植事业的进一步发展提供参考。Liver transplantation is the optimal treatment for end-stage liver disease and hepatocellular carcinoma,which can significantly improve clinical prognosis and quality of life of patients.However,multiple challenges,such as rejection,immune tolerance,shortage of donor liver,preservation of donor liver,ischemia-reperfusion injury and postoperative complications,etc.,limit the efficacy of liver transplantation in clinical practice.Research teams in China have made significant contributions to the basic research related to liver transplantation by making continuous efforts and combining the development of emerging technologies,interdisciplinary integration and other emerging fields.In this article,the frontier progress in the basic research of liver transplantation in 2023 was reviewed,highlighting the progress made by Chinese research teams in the basic research of liver transplantation,aiming to provide reference for promoting the integration of Chinese characteristics into the research of liver transplantation,accelerate the integration of Chinese liver transplantation research with international community,and promote further advancement of liver transplantation in China.

关 键 词：肝移植 排斥反应 免疫耐受 缺血-再灌注损伤 炎症反应 慢性移植物功能障碍 肝细胞癌 肝脏再生 

分 类 号：R617[医药卫生—外科学] R575[医药卫生—临床医学]