肺移植术后气道狭窄的最新研究进展  

Latest research progress in airway stenosis after lung transplantation

作　　者：左玉洁 刘孟根 万佳鑫 陈雨譞 胡文龙 张俊杰 毛宇杨 陈静[3] 钟艾伶 史灵芝 吴波 巨春蓉[5] 田东 Zuo Yujie;Liu Menggen;Wan Jiaxin;Chen Yuxuan;Hu Wenlong;Zhang Junjie;Mao Yuyang;Chen Jing;Zhong Ailing;Shi Lingzhi;Wu Bo;Ju Chunrong;Tian Dong(Department of Thoracic Surgery,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院胸外科,成都610041 [2]四川大学华西医院胸部肿瘤研究所肺移植实验室 [3]川北医学院附属医院心肺移植研究室 [4]南京医科大学无锡医学中心,无锡市人民医院南京医科大学附属无锡人民医院肺移植中心 [5]广州医科大学附属第一医院广州呼吸健康研究院

出　　处：《器官移植》2024年第3期474-478,共5页Organ Transplantation

基　　金：四川省科技厅重点研发基金(23ZDYF2875)。

摘　　要：随着手术技术和术后管理方案的优化,肺移植数量大幅提升,已成为治疗终末期肺病患者的重要手段。但由于支气管缺血和免疫抑制等综合因素的影响,肺移植术后气道狭窄发生率较高,严重影响肺移植受者的术后生存及生活质量。近年来,随着围手术期管理、器官保存及手术技术等的改善,肺移植术后气道狭窄的发生率有所下降,但仍处于较高水平,早期诊断、及时干预对改善气道狭窄患者的预后至关重要。因此,本文就肺移植术后气道狭窄的一般情况、诊断、治疗及预防进行综述,旨在为肺移植术后气道狭窄的综合管理提供参考,以改善肺移植受者预后。With the optimization of surgical technologies and postoperative management regimens,the number of lung transplantation has been significantly increased,which has become an important treatment for patients with end-stage lung disease.However,due to the impact of comprehensive factors,such as bronchial ischemia and immunosuppression,the incidence of airway stenosis after lung transplantation is relatively high,which severely affects postoperative survival and quality of life of lung transplant recipients.In recent years,with the improvement of perioperative management,organ preservation and surgical technologies,the incidence of airway stenosis after lung transplantation has been declined,but it remains at a high level.Early diagnosis and timely intervention play a significant role in enhancing clinical prognosis of patients with airway stenosis.In this article,the general conditions,diagnosis,treatment and prevention of airway stenosis after lung transplantation were reviewed,aiming to provide reference for comprehensive management of airway stenosis after lung transplantation and improving clinical prognosis of lung transplant recipients.

关 键 词：肺移植 气道狭窄 吻合口并发症 缺血 坏死 免疫抑制 肺部感染 机械通气 

分 类 号：R617[医药卫生—外科学] R563[医药卫生—临床医学]