润湿性对脑白质水力渗透率的影响  

Wettability effect on hydraulic permeability of brain white matter

作　　者：苏丽君 雷杰超 李振兴 马驰原 刘少宝 Ljun Su;Jie-Chao Li;Zhenxing Li;Chiyuan Ma;Shaobao Liu(State Key Laboratory of Mechanics and Control for Aerospace Structures,Nanjing University of Aeronautics and Astronautics,Nanjing,210016,China;MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures,Nanjing University of Aeronautics and Astronautics,Nanjing,210016,China;Department of Neurosurgery,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,210002,China)

机构地区：[1]State Key Laboratory of Mechanics and Control for Aerospace Structures,Nanjing University of Aeronautics and Astronautics,Nanjing,210016,China [2]MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures,Nanjing University of Aeronautics and Astronautics,Nanjing,210016,China [3]Department of Neurosurgery,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,210002,China

出　　处：《Acta Mechanica Sinica》2024年第2期244-258,共15页力学学报（英文版）

基　　金：the National Natural Science Foundation of China(Grant Nos.12032010 and 12272179);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX23_0349);the Project of Jiangsu Science and Technology Plan(Grant No.BE2022821).

摘　　要：脑白质可被视为由神经轴突和组织液组成的周期性多孔介质,其水力渗透率反映了组织液在细胞外空间流动的阻力,在水分子运输和药物传递中起着关键作用.细胞外空间的典型宽度为纳米级,组织液流动是具有微尺度的润湿性问题,然而润湿性对渗透性的影响仍然不清楚.本研究将脑白质理想简化为一种周期性纤维多孔介质,考虑流体黏度和滑移边界,以量化润湿性对其水力渗透性的影响.发现流体有效黏度的减小和滑移长度的增加,会导致水力渗透率增大.还发现,对于方形排列的轴突纤维,润湿性对垂直水力渗透率的影响比对平行水力渗透率大;而对于六边形排列的轴突,影响则相反.研究结果可为脑水肿等脑水平衡紊乱疾病治疗及大脑药物传递提供理论指导.With brain white matter can be considered as a periodic fibrous porous medium mainly consisting of axons and interstitial fluid(ISF),the corresponding hydraulic permeability reflects the resistance of ISF flow in the extracellular space(ECS),thus playing a key role in molecular transport and drug delivery.As the ECS exhibits a typical width of 10–80 nm,the ISF flow poses a microscale flow problem with the wettability effect,which may induce a flow with a slip boundary and hence remains elusive.In this study,we idealized brain white matter as a periodic fibrous porous medium to quantify the effect of wettability on its hydraulic permeability,with fluid viscosity and slip boundary duly accounted for.We found that wettability led to enlarged hydraulic permeability by diminishing the effective viscosity and enlarging the slip length.We also found that,for the square arrangement of axons,wettability had a greater effect on perpendicular permeability relative to the parallel one,while for hexagonally arranged axons,the opposite held.Results presented in this study may provide theoretical guidance for cerebral edema treatment regimens and drug delivery.

关 键 词：药物传递 脑白质 神经轴突 润湿性 滑移边界 脑水肿 有效黏度 组织液 

分 类 号：Q51[生物学—生物化学]