多发性硬化损伤的免疫机制研究进展  

Research progress on the immune mechanism of multiple sclerosis injury

作　　者：于倩 赵琳琳[1] 何敏 张惊宇[1] YU Qian;ZHAO Linlin;HE Min;ZHANG Jingyu(Department of Neurology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院神经内科,哈尔滨150001

出　　处：《国际免疫学杂志》2024年第1期74-78,共5页International Journal of Immunology

基　　金：国家自然科学基金(62272138)。

摘　　要：多发性硬化(multiple sclerosis,MS)是中枢神经系统慢性自身免疫性炎性脱髓鞘疾病。既往研究主要探讨T淋巴细胞在MS中的作用,但近年来越来越多的证据表明B淋巴细胞在该病发生发展中发挥了重要作用。文章对T淋巴细胞、B淋巴细胞及细胞因子参与MS的发病机制及相关治疗药物进行概述,以期为MS的治疗提供新的思路。Multiple sclerosis(MS)is a chronic autoimmune inflammatory demyelinating disease of the central nervous system.Previous studies have mainly explored the role of T lymphocytes in MS,but in recent years,more and more evidences have shown that B lymphocytes play an important role in the occurrence and development of this disease.This review summarizes the role of T lymphocytes,B lymphocytes,and cytokines in pathogenesis of MS and related therapeutic drugs,in order to provide new ideas for the treatment.

关 键 词：多发性硬化 T淋巴细胞 B淋巴细胞 细胞因子 

分 类 号：R744.51[医药卫生—神经病学与精神病学]