补肾法调节自噬治疗自然流产的研究思路  

Research ideas on regulating autophagy with kidney-tonifying method to treat spontaneous abortion

作　　者：巫海旺 钟艳兰 罗颂平[1,2] 郜洁 WU Haiwang;ZHONG Yanlan;LUO Songping;GAO Jie(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Guangdong Clinical Research Academy of Chinese Medicine,Guangzhou 510405,China;The First Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院,广州510405 [2]广东省中医临床研究院,广州510405 [3]广州中医药大学第一临床医学院,广州510405

出　　处：《中华中医药杂志》2024年第4期1634-1637,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.82205158);广东省基础与应用基础研究基金项目(No.2021A1515111066);广州市基础研究计划市校(院)联合资助市重点实验室建设项目(No.202201020383);广东省重点领域研发计划项目(No.2020B1111100003);广州中医药大学第一附属医院2023年中青年骨干人才培育项目(No.中医一院〔2023〕186号)。

摘　　要：自然流产是常见的早期妊娠障碍之一,且具有复发倾向,而现代医学治疗流产的方案与手段仍有争论。《黄帝内经》提出了“肾主生殖”理论,成为了中医药安胎的指导思想。目前补肾法安胎疗效已获得中西医认可,但补肾法的安胎机制复杂,其科学内涵尚未完全阐明。自噬是真核细胞内进化高度保守的代谢调控机制,在不同疾病或同一种疾病的不同病理阶段所发挥的作用不一样。目前,自噬在自然流产中扮演的角色尚未明确。文章通过分析自噬与补肾法治疗自然流产的潜在关系,从而拓展补肾安胎作用机制的研究思路,希冀为“肾主生殖”科学内涵提供更多的客观证据。Spontaneous abortion(SA),a common disorder in early pregnancy,has a tendency to recur.However,there is still debate about the schemes and methods of modern medical treatment for SA.The theory of kidney governs reproduction proposed in the Huangdi Neijing has become the guiding principle of traditional Chinese medicine for miscarriage.Currently,the tocolysis effect of kidney-tonifying method has been recognized by both traditional Chinese and Western medicine.However,the mechanism of the kidney-tonifying method in maintaining pregnancy is complex,and its scientific connotation has not been fully explained.Autophagy is a highly conserved metabolic regulation mechanism in eukaryotic cells that plays different roles in various diseases or at different pathological stages of the same disease.Currently,the role of autophagy in SA is not clear.This article explores the potential relationship between autophagy and the treatment of SA using kidney-tonifying method,thereby expanding the research ideas on the mechanism of kidney-tonifying in maintaining pregnancy,with the hope of providing more objective evidence for the scientific meaning of‘kidney governs reproduction’.

关 键 词：自噬 自然流产 补肾法 减味寿胎丸 肾主生殖 

分 类 号：R271.9[医药卫生—中西医结合]