2546例新型冠状病毒奥密克戎变异株感染康复期患者流行病学调查的中医临床证候规律  

Study on the law of clinical symptoms of traditional Chinese medicine in the epidemiological survey of 2546 patients with Omicron variants infection

作　　者：王淼 吕文亮[1,2] 张涵灵 杨瑞华[1,2] 闫海琳 张新悦 刘之义 何嘉伟 黄超群[1,4] 王传池 周姝含 徐婧 WANG Miao;LYU Wenliang;ZHANG Hanling;YANG Ruihua;YAN Hailin;ZHANG Xinyue;LIU Zhiyi;HE Jiawei;HUANG Chaoqun;WANG Chuanchi;ZHOU Shuhan;XU Jing(Institute of Epidemic Research,Hubei University of Chinese Medicine,Wuhan 430061,China;College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430061,China;Xin-Huangpu Joint Innovation Institute of Chinese Medicine,Guangzhou 510700,China;Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430060,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]湖北中医药大学疫病研究所,武汉430061 [2]湖北中医药大学中医学院,武汉430061 [3]广东省新黄埔中医药联合创新研究院,广州510700 [4]湖北省中医院,武汉430060 [5]天津中医药大学,天津301617

出　　处：《中华中医药杂志》2024年第4期2081-2086,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局中医药创新团队及人才支持计划项目(No.ZYYCXTD-D-202203);湖北省自然科学基金项目(No.2023AFD138);湖北省科学技术厅重点研发计划项目(No.2020BCB015);广东省新黄埔中医药联合创新项目(No.20220TH003)。

摘　　要：目的:分析湖北省2546例新型冠状病毒奥密克戎变异株感染康复期患者的流行病学调查结果,探讨其临床证候的规律。方法:利用“问卷星”于线上展开问卷调查,收集2022年12月1日至2023年1月31日湖北省新型冠状病毒奥密克戎变异株感染患者2546例作为研究对象,采用卡方分析、因子分析等方法,分析本次新型冠状病毒感染康复期患者的主要中医临床症状、病位、病性以及患者基础疾病与康复期症状的相关性。结果:主要中医临床症状有咳嗽、乏力疲倦、食欲不振、咯痰(白痰)、恶风恶寒、味觉障碍等。病位主要在肺、脾,病性主要为虚实夹杂,包括气虚、阴虚等。高血压病患者的乏力疲倦、恶风恶寒发生率显著高于非高血压病患者(P<0.01),高脂血症患者的乏力疲倦、味觉障碍发生率显著高于非高脂血症患者(P<0.05),糖尿病患者的味觉障碍的发生率显著高于非糖尿病患者(P<0.01),冠心病患者的食欲不振发生率显著高于非冠心病患者(P<0.05),肿瘤患者的味觉障碍发生率显著高于非肿瘤患者(P<0.05),慢性肺病患者的恶风恶寒发生率显著高于非慢性肺病患者(P<0.05)。结论:湖北省本轮新型冠状病毒感染疫情康复期中医临床症状多与肺脾相关,病性以气虚、阴虚、湿阻为主。Objective:To analyze the results of epidemiological survey of 2546 recovered patients infected with the Omicron variant of the novel coronavirus in Hubei Province,and to explore the pattern of their clinical symptoms.Methods:A questionnaire survey was conducted online using‘Questionnaire Star’to collect 2546 patients infected with the Omicron variant of the new coronavirus in Hubei Province from December 1,2022 to January 31,2023,and analyze the main Chinese clinical symptoms,pathologic symptoms and symptoms of patients recovering from the new coronavirus infection,by using chi-square analysis,factor analysis and other methods.The correlation between the main Chinese clinical symptoms,location and nature of the disease,and the underlying diseases of the patients and the symptoms during the recovery period were analyzed.Results:The main TCM clinical symptoms included cough,tiredness and fatigue,loss of appetite,sputum(white sputum),afraid of wind and cold,and taste disorder etc..The disease center was mainly in the lung and spleen,and the pathology was mainly a mixture of deficiency and solidity,including qi deficiency and yin deficiency.The incidence of tiredness and fatigue,afraid of wind and cold were significantly higher in hypertensive patients than those in non-hypertensive patients(P<0.01),the incidence of tiredness and fatigue,and taste disorder in hyperlipidemic patients were significantly higher than those in non-hyperlipidemic patients(P<0.05),the incidence of taste disorder in diabetic patients was significantly higher than that in non-diabetic patients(P<0.01),the incidence of loss of appetite in patients with coronary heart disease was significantly higher than that in patients with coronary heart disease(P<0.05),the incidence of taste disorders in tumor patients was significantly higher than that in non-tumor patients(P<0.05),and the incidence of afraid of wind and cold in patients with chronic lung disease was significantly higher than that in patients without chronic lung disease(P<0.05).Concl

关 键 词：新型冠状病毒感染 康复期 中医证候规律 因子分析 奥密克戎 

分 类 号：R259[医药卫生—中西医结合]