冠心病合并糖尿病患者经皮冠状动脉介入术后支架内再狭窄危险因素的研究进展  

Research progress on risk factors of in-stent restenosis in patients with coronary atherosclerotic heart disease and diabetes mellitus after percutaneous coronary intervention

作　　者：罗鸿池 马涵英[1] 韩红亚[2] 李亚冬[1] 刘晓丽[2] 赵铁夫[1] Luo Hongchi;Ma Hanying;Han Hongya;Li Yadong;Liu Xiaoli;Zhao Tiefu(Department of General Medicine,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Elderly Cardiovascular Center,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院全科医疗科,北京100029 [2]首都医科大学附属北京安贞医院老年心血管病中心,北京100029

出　　处：《中国医药》2024年第5期763-767,共5页China Medicine

基　　金：国家重点研发计划(2022YFC3602502);北京市高层次公共卫生技术人才培养计划(学科带头人2022-2-008;学科骨干-02-01)。

摘　　要：冠心病(冠状动脉粥样硬化性心脏病)合并糖尿病患者冠状动脉支架内再狭窄率显著高于未合并糖尿病患者。其特征以糖代谢异常、血糖波动、胰岛素抵抗为核心,且往往伴发高脂血症、高尿酸血症、凝血及纤维蛋白溶解指标异常、慢性炎症等,这些因素直接或间接影响了血管内皮功能,促使平滑肌增生、凝血异常等,并最终导致再狭窄的发生。本综述主要针对糖尿病合并冠心病患者经皮冠状动脉介入术后支架内再狭窄危险因素的研究进行总结探讨,以期为临床降低支架内再狭窄发生率及预防不良心血管事件的发生提供参考依据。The rate of in-stent restenosis in patients with coronary atherosclerotic heart disease and diabetes mellitus is significantly higher than that in patients without diabetes mellitus.It is characterized by abnormal glucose metabolism,blood glucose fluctuation,insulin resistance as the core,and is often accompanied by hyperlipidemia,hyperuricemia,abnormal coagulation and fibrinolysis indicators,chronic inflammation,etc.These factors directly or indirectly affect vascular endothelial function,promote smooth muscle proliferation,abnormal coagulation,and ultimately lead to the occurrence of restenosis.This review mainly summarizes and discusses the research on the risk factors of in-stent restenosis after percutaneous coronary intervention in patients with diabetes mellitus and coronary atherosclerotic heart disease,in order to provide a reference for reducing the incidence of in-stent restenosis and preventing the occurrence of adverse cardiovascular events.

关 键 词：冠心病(冠状动脉粥样硬化性心脏病) 糖尿病 支架内再狭窄 经皮冠状动脉介入 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]