雷公藤甲素防治卵巢癌的作用机制研究进展  

Research progress on mechanism of triptolide in prevention and treatment of ovarian cancer

作　　者：杨丽慧[1] 张培[1] 李秀伟 YANG Lihui;ZHANG Pei;LI Xiuwei(Xingtai Medical College,Xingtai 054000,China;Department of Gynecology,Shijiazhuang City Luancheng People's Hospital,Shijiazhuang 051430,China)

机构地区：[1]邢台医学高等专科学校,河北邢台054000 [2]石家庄市栾城人民医院妇科,河北石家庄051430

出　　处：《现代药物与临床》2024年第3期791-796,共6页Drugs & Clinic

基　　金：河北省卫生和计划生育委员会科研项目(20171027)。

摘　　要：卵巢癌是第2大普遍存在的妇科恶性肿瘤,具有较高的死亡率。化疗是卵巢癌主要的治疗手段,但大多数患者会发生化疗耐药性。雷公藤甲素是从雷公藤中提取的天然活性二萜类化合物,具有多种药理活性。雷公藤甲素可以通过抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、降低卵巢癌侵袭力、降低卵巢癌对顺铂耐药性、调节卵巢癌细胞周期、增强抗肿瘤免疫应答、改变肿瘤微环境发挥多途径防治卵巢癌。归纳了雷公藤甲素防治卵巢癌的作用机制,为卵巢癌的临床治疗提供依据。Ovarian cancer is the second most common gynecological malignancy with a high mortality rate.Chemotherapy is the main treatment for ovarian cancer,but most patients will develop chemotherapy resistance.Tripterygiolide is a naturally active diterpenoid compound extracted from Tripterygii Wilfordii Radix et Rhizoma,with various pharmacological activities.Triptolide can play a multiple pathways to prevent and treat ovarian cancer by inhibiting tumor cell proliferation,promoting cell apoptosis,reducing invasiveness of ovarian cancer,reducing tumor cell resistance against cisplatin,regulating ovarian cancer cell cycle,enhancing anti-tumor immune response,and altering the tumor microenvironment.This article summarizes the mechanism of triptolide in prevention and treatment of ovarian cancer,providing a basis for the clinical treatment for ovarian cancer.

关 键 词：雷公藤甲素 卵巢癌 细胞增殖 细胞凋亡 侵袭力 耐药性 细胞周期 免疫应答 肿瘤微环境 

分 类 号：R285[医药卫生—中药学] R984[医药卫生—中医学]