恒河猴肠道寄生虫感染情况调查与控制  

Investigation and Control of Intestinal Parasite Infection in Rhesus Monkeys

作　　者：冉艳洪 王俐梅 颜欣欣 周珊珊 宋慧 杨威 Ran Yanhong;Wang Limei;Yan Xinxin;Zhou Shanshan;Song Hui;Yang Wei(Guangzhou Bay Area Institute of Biomedicine,Guangdong Lewwin Pharmaceutical Research Institute Co.,Ltd.,Guangdong Key Laboratory of Drug Non-Clinical Evaluation and Research,TCM Non-clinic Evaluation Branch ofNational Engineering Research Center for Modernization of Traditional Chinese Medicine,Guangdong EngineeringResearch Center for Innovative Drug Evaluation and Research,Guangzhou 510990,Guangdong,China)

机构地区：[1]广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价研究企业重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东广州510990

出　　处：《中国动物检疫》2024年第4期11-15,共5页China Animal Health Inspection

基　　金：广东省重点领域研发计划项目(2023B1111050008);广东省重大人才工程项目(210183503006);广东省实验室建设项目(2023B1212070029)。

摘　　要：为了解恒河猴在实验室饲养环境下的肠道寄生虫感染情况,采用直接涂片法和饱和食盐水漂浮法,对采集的66只试验用恒河猴新鲜粪便进行肠道寄生虫检查,并评估了血液学、血液生化学相关指标以及驱虫药物的驱虫效果。结果显示:从66只恒河猴新鲜粪便中检出类圆线虫和鞭虫2种肠道蠕虫卵囊,感染率分别是9.1%和12.1%,均为单一感染且感染强度较低;感染类圆线虫或鞭虫恒河猴的血液学指标(WBC、RBC、HGB、MCH、MCHC、HCT、MCV、PLT、PDW、MPV、PCT、LYMPH、MONO、EO、BASO)和肝肾功能指标(ALT、AST、ALP、LDH、TP、BUN、CREA)与健康动物无显著差异(P>0.05);连续使用伊维菌素注射液或阿苯达唑伊维菌素片均能有效驱除感染的类圆线虫或鞭虫。结果说明:恒河猴在实验室饲养环境下,其肠道寄生虫的感染种类较少,感染率和感染强度均较低,对动物健康状况无明显影响,通过良好的饲养管理和完善的药物驱虫程序能实现对猴肠道寄生虫病的有效控制。In order to investigate the infection with intestinal parasites in rhesus monkeys under laboratory environment,fresh feces from 66 experimental rhesus monkeys were detected for intestinal parasites using direct smear and saturated saline floatation methods,haematological and haematobiochemical indicators as well as anthelmintic efficacy of anthelmintic drugs were evaluated.The results showed that two types of intestinal worm oocysts including Strongyloides and Trichuridae were detected out,with infection rates of 9.1%and 12.1%,respectively,both of which were single infection with low intensify;for the infected monkeys,the haematological indicators(WBC,RBC,HGB,MCH,MCHC,HCT,MCV,PLT,PDW,MPV,PCT,LYMPH,MONO,EO and BASO)and hepatorenal function indicators(ALT,AST,ALP,LDH,TP,BUN and CREA)were not significantly different from those of healthy animals(P>0.05);and the active Strongyloides or Trichuridae could be effectively removed by continuously using ivermectin injection or albendazole ivermectin tablets.In conclusion,the rhesus monkeys were infected with fewer types of intestinal parasites under experimental environment,with low infection rate and intensity,imposing little effect on animal health,and could effectively recover through good feeding management and sound procedure of drug deworming.

关 键 词：恒河猴 肠道寄生虫 类圆线虫 鞭虫 感染 控制 

分 类 号：S855.9[农业科学—临床兽医学]