2型糖尿病患者左室心肌力学特性参数与血25(OH)D、hs-CRP及IL-6表达的相关性  

Correlation between LV myocardial mechanical characteristic parameters and blood 25(OH)D,hs-CRP and IL-6 expression in patients with type 2 diabetes

作　　者：郭龙宇 Guo Longyu(Department of Endocrine Metabolism,Anyang Iron and Steel Group Co.,Ltd.Employee General Hospital,Anyang,Henan 455004,China.)

机构地区：[1]安阳钢铁集团有限责任公司职工总医院,河南安阳455004

出　　处：《齐齐哈尔医学院学报》2024年第8期716-720,共5页Journal of Qiqihar Medical University

摘　　要：目的研究2型糖尿病患者左室心肌力学特性参数与血25-羟基维生素D(25(OH)D)、高敏C反应蛋白(hs-CRP)及白细胞介素-6(IL-6)表达的相关性。方法选择2021年1月—2023年2月本院收治的103例2型糖尿病患者作为观察组,依据血糖控制是否良好分为血糖良好组(82例)和血糖不良组(21例);另选取同期来本院体检的90名健康者作为对照组。比较观察组与对照组一般资料、左室心肌力学特性参数(左室舒张末期内径、左室后壁舒张末期厚度、左室收缩末期内径、左室射血分数)、25(OH)D、hs-CRP及IL-6水平,比较血糖良好组与血糖不良组左室心肌力学特性参数(左室舒张末期内径、左室后壁舒张末期厚度、左室收缩末期内径、左室射血分数)、25(OH)D、hs-CRP及IL-6水平。结果观察组与对照组性别、年龄、身体质量指数(BMI)、舒张压、收缩压、吸烟史、饮酒史、高血压史、糖尿病史、总胆固醇、血红蛋白(Hb)、钙、磷、白细胞(WBC)及尿酸比较,差异无统计学意义(P>0.05);观察组与对照组左室射血分数比较,差异无统计学意义(P>0.05),观察组左室舒张末期内径、左室后壁舒张末期厚度、左室收缩末期内径、hs-CRP及IL-6高于对照组(P<0.05),观察组25(OH)D水平低于对照组(P<0.05);不同血糖控制水平两组左室收缩末期内径、左室射血分数比较,差异无统计学意义(P>0.05),血糖良好组左室舒张末期内径、左室后壁舒张末期厚度、hs-CRP及IL-6低于血糖不良组(P<0.05),血糖良好组25(OH)D高于血糖不良组(P<0.05);Pearson相关分析结果显示:左室舒张末期内径、左室后壁舒张末期厚度、左室收缩末期内径均与25(OH)D呈负相关(P<0.05),与hs-CRP、IL-6呈正相关(P<0.05)。结论2型糖尿病患者心脏结构及25(OH)D、hs-CRP、IL-6水平发生改变,且左室心肌力学特性参数与25(OH)D,hs-CRP、IL-6水平相关。Objective To study the correlation between the mechanical characteristic parameters of the left ventricular myocardium and the expression of blood 25-hydroxyvitamin D(25(OH)D),high-sensitivity C-responsive protein(hs-CRP)and interleukin-6(IL-6)in patients with type 2 diabetes mellitus.Methods 103 cases of type 2 diabetes patients who were admitted to our hospital from January 2021 to February 2023 were selected as the observation group,they were divided into the good blood glucose group(82 cases)and the poor blood glucose group(21 cases)according to whether the blood glucose control was good.90 healthy patients who came to our hospital during the same period were selected as the control group.The general data,the parameters[left ventricular end-diastolic diameter,LV back wall end-diastolic thickness,left ventricular end-systolic diameter,left ventricular ejection fraction],25(OH)D,hs-CRP,and IL-6 levels of the observation group and the control group were compared,and the parameters[the left ventricular end-diastolic diameter,left ventricular posterior wall end-diastolic thickness,left ventricular end-systolic diameter,LV ejection fraction],25(OH)D,hs-CRP,and IL-6 levels were compared between good blood glucose group and poor blood glucose group.Results There were no significant differences in gender,age,body mass index(BMI),diastolic blood pressure,systolic blood pressure,smoking history,alcohol consumption history,history of hypertension,history of diabetes mellitus,total cholesterol,hemoglobin(Hb),calcium,phosphorus,white blood cells(WBC)and uric acid between the observation group and the control group(P>0.05).There was no significant difference in left ventricular ejection fraction between the observation and the control group(P>0.05).The LV end diastolic diameter,LV back wall end diastolic thickness,LV end systolic diameter,hs-CRP and IL-6 in the observation group were higher than those in the control group(P<0.05).The level of 25(OH)D in the observation group was lower than that in the control group(P<0.05).

关 键 词：左室心肌力学特性参数 25-羟基维生素D 高敏C反应蛋白 白细胞介素-6 左室舒张末期内径 左室后壁舒张末期厚度 左室收缩末期内径 

分 类 号：R587.1[医药卫生—内分泌]