不同食盐摄入水平对辅助生殖技术女性首次移植周期助孕结局的影响  

Effect of the salt intake levels on clinical outcomes of the first transfer cycle in women undergoing assisted reproductive technology

作　　者：岳峰 张少娣 徐嘉宁 崔趁趁 王倩 张翠莲 Yue Feng;Zhang Shaodi;Xu Jianing;Cui Chechen;Wang Qian;Zhang Cuilian(Reproductive Medicine Center of Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou 450003)

机构地区：[1]郑州大学人民医院、河南省人民医院生殖医学中心,郑州450003

出　　处：《中华生殖与避孕杂志》2024年第3期272-277,共6页Chinese Journal of Reproduction and Contraception

摘　　要：目的研究不同食盐摄入水平对行辅助生殖技术助孕女性首次移植周期妊娠结局的影响。方法回顾性队列研究分析2021年1月至2021年7月期间于河南省人民医院生殖医学中心接受体外受精/卵胞质内单精子注射-胚胎移植助孕首次移植周期的163例患者的资料。点尿法近似估算患者的24 h钠盐摄入量,并以其第25和第75百分位数将所有患者分为3组:低盐组(≤9.21 g,n=41)、中盐组(9.22~13.31 g,n=81)和高盐组(≥13.32 g,n=41)。分析比较各组间控制性促排卵指标及移植后临床结局。通过多因素logistic回归分析调整混杂因素后分析3组患者的临床结局。结果高盐组患者的MⅡ卵率[72.7%(410/564)]、优质胚胎率[42.1%(109/259)]低于低盐组患者[82.5%(461/559),52.4%(154/294),均P<0.05],3组间比较差异均有统计学意义(P<0.001,P=0.048)。中盐组患者其双原核卵裂率[99.1%(568/573)]高于低盐组患者[96.1%(294/306),P<0.05],3组间比较差异有统计学意义(P=0.003)。胚胎种植率、临床妊娠率、早期流产率、活产率,各组间差异均无统计学意义(均P>0.05)。调整可能的混杂因素后,中盐组的临床妊娠率(OR=0.520,95%CI:0.221~1.221,P=0.133)、早期流产率(OR=1.226,95%CI:0.219~6.851,P=0.817)、活产率(OR=0.730,95%CI:0.323~1.647,P=0.448)及高盐组的临床妊娠率(OR=0.659,95%CI:0.246~1.762,P=0.406)、早期流产率(OR=1.080,95%CI:0.162~7.180,P=0.937)、活产率(OR=1.012,95%CI:0.396~2.588,P=0.980)与低盐组相比,其差异均无统计学意义。结论高食盐摄入水平并不影响首次助孕移植周期的临床妊娠结局,但对卵子成熟、正常卵裂及优质胚胎形成有不利影响。Objective To explore the effect of different salt intake levels on clinical outcomes after the first embryo transfer in women undergoing assisted reproductive technology.Methods This was a retrospective cohort study.A total of 163 patients with the first in vitro fertilization/intracytoplasmic sperm injection and embryo transfer from January 2021 to July 2021 in Reproductive Medical Center,Henan Provincial People's Hospital were recruited.The spot urine method was used to estimate the 24 h salt intake of patients,and all patients were divided into three groups based on their 25th and 75th percentiles:low-salt group(≤9.21 g,n=41),medium-salt group(9.22-13.31 g,n=81),and high-salt group(≥13.32 g,n=41).Baseline data and clinical outcomes were analyzed and compared among the three groups.Results The rate of MII oocyte[72.7%(410/564)],and the rate of high-quality embryos[42.1%(109/259)]in the high-salt group were lower than those in the low-salt group[82.5%(461/559),P<0.05;52.4%(154/294),P<0.05],the differences among the three groups were statistically significant(P<0.001,P=0.048).The rate of normal cleavage[99.1%(568/573)]in the medium-salt group was higher than that in the low-salt group[96.1%(294/306),P<0.05],and the difference among the three groups was statistically significant(P=0.003).After adjusting for potential confounding factors by using multivariate logistic regression,the clinical pregnancy rate(OR=0.520,95%CI:0.221-1.221,P=0.133),the early miscarriage rate(OR=1.226,95%CI:0.219-6.851,P=0.817),and the live birth rate(OR=0.730,95%CI:0.323-1.647,P=0.448)in the medium-salt group,the clinical pregnancy rate(OR=0.659,95%CI:0.246-1.762,P=0.406),the early miscarriage rate(OR=1.080,95%CI:0.162-7.180,P=0.937),and the live birth rate(OR=1.012,95%CI:0.396-2.588,P=0.980)in the high-salt group were comparable with the low-salt group(all P>0.05).Conclusion High level of salt intake does not affect the clinical pregnancy outcomes of infertile women in their first transplantation cycle.However,it has an adverse effec

关 键 词：受精 体外 胚胎移植 盐摄入 点尿法 

分 类 号：R714.8[医药卫生—妇产科学]