不同促排卵方案在波塞冬低预后患者IVF/ICSI治疗中的应用进展  

Progress in the application of different controlled ovarian stimulation protocols in IVF/ICSI treatment for POSEIDON patients

作　　者：祝婷 周郁恬 王超仪 孟艳[1] Zhu Ting;Zhou Yutian;Wang Chaoyi;Meng Yan(Center of Clinical Reproductive Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院生殖医学中心,南京210029

出　　处：《中华生殖与避孕杂志》2024年第3期304-309,共6页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(82271668)。

摘　　要：接受辅助生殖技术治疗中的低预后患者主要表现为卵巢对外源性促性腺激素刺激反应不良、临床妊娠率低于同龄正常反应者,既往此类人群采用博洛尼亚标准定义和诊断。为了提高研究人群的同质性,2016年波塞冬小组提出了新的低预后人群细分标准即波塞冬标准,概念上从"低反应"转向"低预后",为低预后患者提供了临床咨询和治疗建议的分类依据。现有多种控制性促排卵方案应用于不同亚组的波塞冬低预后人群,在不同亚组人群中的临床应用各有利弊。本文将对波塞冬分组标准下的低预后患者接受不同控制性超促排卵方案及辅助用药的临床应用进展进行阐述及总结。Patients with low-prognosis undergoing in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)treatment are mainly manifested as poor ovarian response to exogenous gonadotropin stimulation and a lower clinical pregnancy rate than normal responders of the same age.In the past,Bologna criteria was used to define and diagnose those patients.In 2016,the Patient Oriented Strategies Encompassing Individualized Oocyte Number(POSEIDON)group proposed a new subdivision standard for low prognosis population in order to improve the homogeneity of them,which conceptually moved from poor response to poor prognosis and provided a classification basis for clinical treatment guidance and clinical counselling for POSEIDON patients.There are various controlled ovarian hyperstimulation protocols applied to POSEIDON groups,which have different effects on clinical application among different subgroups.This article will describe and summarize the progress of different ovulation induction regimens and adjuvant treatment strategies for patients with low-prognoses based on the POSEIDON criteria.

关 键 词：生殖技术 辅助 卵巢刺激 控制性超促排卵方案 波塞冬标准 低预后 卵巢低反应 

分 类 号：R714.8[医药卫生—妇产科学]