Telocytes对妊娠的影响及可能机制  

Effect of telocytes on pregnancy and its mechanism

作　　者：史亚兰 邓凯贤 Shi Yalan;Deng Kaixian(Department of Gynecology,Shunde Hospital of Southern Medical University the First People's Hospital of Shunde,Shunde 528300,China)

机构地区：[1]南方医科大学顺德医院顺德第一人民医院妇科,顺德528300

出　　处：《中华生殖与避孕杂志》2024年第3期320-324,共5页Chinese Journal of Reproduction and Contraception

摘　　要：妊娠的建立依赖于胚胎的胎盘绒毛膜外细胞滋养细胞合适的侵袭、母胎间的血管重铸及母胎免疫耐受。近年来,特洛细胞(telocytes,TCs)作为一种新型的间质细胞被广泛报道,它可与同种细胞或其他类型细胞相互连接,参与组织再生和修复过程、信号转导、肌肉收缩协调的起搏、分泌功能和局部微环境的免疫调节、免疫监测,从而形成复杂的三维网络,发挥重要的作用。其中它在妊娠及相关疾病中的研究也是热点之一。本文通过对TCs在妊娠中的作用及可能机制进行综述,为探究TCs在胚胎着床及妊娠维持中的作用提供更多依据。The success of pregnancy relies on moderate trophoblast invasion,sufficient vascular remodeling and maternal-fetal tolerance.Recently,telocytes(TCs)have been widely reported as a novel type of interstitial cells.Functionally,TCs form a three-dimensional interstitial network by homocellular and heterocellular communication and are involved in tissue repair and regeneration,signal transduction,muscle contraction,secretion and immune regulation.One of the hotspots is the study of TCs in pregnancy establishment and pathological pregnancy.This paper reviews the role and possible mechanism of TCs on pregnancy,so as to provide more basis for exploring the role of TCs in embryo implantation and pregnancy maintenance.

关 键 词：特洛细胞 妊娠 滋养层细胞 

分 类 号：R714[医药卫生—妇产科学]