血管内皮细胞调控血管平滑肌细胞表型的机制及其在动脉血管疾病中的作用研究进展  

Research advances in regulation of vascular smooth muscle cell phenotypes by vascular endothelial cells in arterial vascular diseases

作　　者：高丹 张信信 韩骅 晏贤春 GAO Dan;ZHANG Xinxin;HAN Hua;YAN Xianchun(Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Air Force Medical University,Xi’an 710032,Shaanxi Province,China;Faculty of Life Sciences,Northwest University,Xi’an 710069,Shaanxi Province,China;Department of Respiratory and Critical Care Medicine,the Eighth Medical Center,Chinese PLA General Hospital,Beijing 100091,China)

机构地区：[1]空军军医大学基础医学院生物化学与分子生物学教研室,陕西西安710032 [2]西北大学生命科学学院,陕西西安710069 [3]解放军总医院第八医学中心呼吸与危重医学部,北京100091

出　　处：《解放军医学院学报》2024年第1期100-104,F0003,共6页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(82103446,32270966);陕西省高校科协青年人才托举计划(20210301)。

摘　　要：血管内皮细胞(vascular endothelial cells,VECs)与血管平滑肌细胞(vascular smooth muscle cells,VSMCs)在结构上紧密相连,在功能上互相影响。VECs可通过直接(Notch信号通路)或间接(细胞因子、外泌体)方式调控VSMCs表型转变,以应对缺氧、炎症或异常机械力等刺激并维持血管稳态,该过程异常是导致动脉粥样硬化、主动脉瘤、主动脉夹层等动脉血管疾病的重要原因。本文将对VECs调控VSMCs表型转变的机制及其在动脉血管疾病中的作用做一综述。Vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)are closely connected and affect each other functionally.VECs can regulate the phenotypic transition of VSMCs directly(Notch signaling pathway)or indirectly(cytokines,exosomes)in respond to external stimuli such as hypoxia,inflammation or abnormal mechanical forces and maintain vascular homeostasis.The abnormal process is an important cause of arterial vascular diseases such as atherosclerosis,aortic aneurysm and aortic dissection.In this paper,the mechanism of VECs regulating phenotypic transformation of VSMCs is reviewed.

关 键 词：血管内皮细胞 血管平滑肌细胞 动脉血管疾病 表型转变 血管稳态 

分 类 号：R543.5[医药卫生—心血管疾病]