深在性硬斑病1例  

Deep Morphea:A Case Report

作　　者：姜蔚蔚 张峻岭[1] 王磊[1] 郭涛[1] 马秀亮[1] JIANG Weiwei;ZHANG Junling;WANG Lei;GUO Tao;MA Xiuliang(Department of Dermatology,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin Institute of Integrative Dermatology,Tianjin 300120,China)

机构地区：[1]天津市中医药研究院附属医院皮肤科,天津市中西医结合皮肤病研究所,天津300120

出　　处：《中国皮肤性病学杂志》2024年第5期570-572,共3页The Chinese Journal of Dermatovenereology

摘　　要：深在性硬斑病属于硬斑病中的少见类型,临床医生往往经验较少,易被误诊、漏诊。本文报告1例深在性硬斑病,患者女,59岁,双小腿红斑、肿胀、硬化4个月余。抗核抗体谱示ANA 1∶160,抗着丝点抗体(+),抗可溶性核抗原抗体阳性(+),抗线粒体抗体(+)。皮损组织病理示:真皮深层胶原束增粗、硬化,皮下脂肪间隔增宽,间隔内及部分脂肪小叶内较多淋巴细胞浸润。诊断:深在性硬斑病。予甲泼尼龙、硫酸羟氯喹抗炎治疗,皮损好转,随访1年未见复发。Deep morphea is a rare type of morphea,which is easy to be misdiagnosed and missed diagnosis.This article reported a case of deep morphea.A 59-year-old female presented with erythema,swelling and induration on both lower legs for more than four months.The ANA was 1∶160,anti centromere antibody,anti soluble nuclear antigen antibody,and anti mitochondrial antibody were positive.Histopathology results showed thickening and hardening of collagen bundles in the deepdermis,widening of the subcutaneous fat septum,and more lymphocyte infiltration in the septum and some fat lobules.The diagnosis of deep morphea was established.The lesions were improved after anti-inflammatory treatment with methylprednisolone and hydroxychloroquine.No recurrence was observed during one-year follow-up.

关 键 词：深在性硬斑病 硬皮病性脂膜炎 

分 类 号：R593.25[医药卫生—内科学]