饲喂刺五加茯苓粉对小鼠镇静催眠作用的影响  

Effect of feeding Poria cocos and Acanthopanax powder on sedative and hypnotic effect in mice

作　　者：黄颖聪 屈琳琳 HUANG Yingcong;QU Linlin(School of Chemical Engineering,Northwest University,Xi’an 710069;Biotech.and Biomed.Research Institute,Northwest University,Xi’an 710069)

机构地区：[1]西北大学化工学院,西安710069 [2]西北大学生物医药研究院,西安710069

出　　处：《中国食品添加剂》2024年第4期147-152,共6页China Food Additives

基　　金：国家重点研发计划项目(编号:2021YFC2101500);陕西省重点研发计划项目(编号:2022ZDLSF05-12)。

摘　　要：通过检测小鼠的直接睡眠、延长戊巴比妥钠睡眠时间及小鼠脑组织中5-HT、GABA和DA含量变化等实验来评价刺五加水提物、茯苓水提物、刺五加茯苓粉对小鼠睡眠的影响。结果表明与对照组相比,刺五加水提物、茯苓水提物、刺五加茯苓粉均能延长戊巴比妥钠诱导的小鼠睡眠时间以及增加入睡小鼠只数(P<0.05),缩短小鼠的睡眠潜伏期(P<0.05),且刺五加茯苓粉高剂量组效果最好。此外,刺五加水提物、茯苓水提物、刺五加茯苓粉可以显著增加小鼠脑组织中5-HT及GABA含量,降低DA含量,表明刺五加水提物、茯苓水提物、刺五加茯苓粉均具有改善小鼠睡眠的作用,且刺五加茯苓粉对小鼠的改善睡眠作用表现出一定的协同增效效果。The effects of Acanthopanax aqueous extract,Poria cocos aqueous extract and Acanthopanax Poria cocos powder on mouse sleep were evaluated by detecting the direct sleep time,prolonged sodium pentobarbital sleep time and changes of 5-HT,GABA and DA contents in mouse brain tissue.The results showed that compared with the control group,Acanthopanax aqueous extract,Poria cocos aqueous extract and Acanthopanax Poria cocos powder could prolong the sleep time of mice and the number of sleeping mice induced by sodium pentobarbital(P<0.05)and shorten the sleep latency of mice(P<0.05),and the high dose group of Acanthopanax Poria cocos powder had the best effect.In addition,Acanthopanax aqueous extract,Poria cocos aqueous extract and Acanthopanax Poria cocos powder could significantly increase the 5-HT and GABA content and decrease the DA content in the brain tissue of mice,indicating that Acanthopanax aqueous extract,Poria cocos aqueous extract and Acanthopanax Poria cocos powder all had the effect of improving sleep in mice,and Acanthopanax Poria cocos powder showed a certain synergistic effect on the improvement of sleep in mice.

关 键 词：刺五加 茯苓 水提物 改善睡眠 戊巴比妥钠 巴比妥钠 

分 类 号：R932[医药卫生—生药学]