趋化素和胱抑素C与原发性高血压左心室肥厚的相关性  

Relationship between cystatin C,insulin growth factor-1 and left ventricular hypertrophy secondary to type H hypertension

作　　者：顾玉[1] 刘秋霞[1] 张树良[2] 王媛媛 王晓成[1] Gu Yu;Liu Qiuxia;Zhang Shuliang(Laboratory,Chengde Central Hospital,Chengde 067000,China)

机构地区：[1]承德市中心医院检验科,067000 [2]承德市中心医院心内科,067000

出　　处：《中华保健医学杂志》2024年第2期162-164,共3页Chinese Journal of Health Care and Medicine

基　　金：承德市科学技术研究与发展计划项目(202002A017)。

摘　　要：目的观察血清胱抑素C(cystatin C,Cys C)、趋化素(Chemerin)对原发高血压患者继发左心室肥厚(left ventricular hypertrophy,LVH)的影响。方法选取2020年3月~2023年3月在承德市中心医院就诊的中老年高血压患者122例,根据超声心动检查分为左心室肥厚(LVH)组45例,无左心室肥厚(NLVH)组77例。另同期在本院检行超声心动检查无高血压的60名健康体检者作为健康对照组。比较患者病程、用药等一般临床资料、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、尿素氮(UN)、肌酐(Cr)、Cys C、Chemerin、同型半胱氨酸(homocysteine,Hcy)指标。采用Pearson进行相关分析,logistic回归分析左心室肥厚的影响因素。结果NLVH组和LVH组体质量指数(BMI)、TC、收缩后(SBP)、舒张后(DBP)、Cys C、Chemerin、Hcy水平均高于健康对照组,LVH组BMI、SBP、DBP、Cys C、Chemerin、Hcy水平高于NLVH组,差异均有统计学意义(P<0.05)。NLVH组吸烟人数和Cr水平高于健康对照组,差异有统计学意义(P<0.05),但与LVH组比较,差异无统计学意义(P>0.05)。Cys C、Chemerin与左心室质量指数呈正相关,相关系数分别为0.305、0.182。多因素回归分析显示,SBP、肥胖、Cys C、Chemerin、Hcy是影响LVH发生的独立风险因素。结论Cys C、Chemerin参与左心室肥厚的病理发展过程,是中老年原发性高血压患者继发左心室肥厚的独立危险因素。Objective To observe the effects of serum cystatin C(Cys C)and Chemerin on secondary left ventricular hypertrophy(LVH)in patients with primary hypertension.Methods The study subjects were middle-aged and elderly hypertensive patients who visited our hospital from March 2020 to March 2023.According to echocardiography,they were divided into a left ventricular hypertrophy group(LVH group)of 45 cases and non left ventricular hypertrophy group(NLVH group)of 77 cases.During the same period,echocardiography was performed in our hospital,with 60 healthy individuals without hypertension as the control group.Compare general clinical data such as patient course and medication,total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FPG),urea nitrogen(UN),creatinine(Cr),Cys C,Chemerin,and homocysteine(Hcy).Pearson correlation analysis and logistic regression analysis were used to analyze the influencing factors of left ventricular hypertrophy.Results The BMI,TC,SBP,DBP,Cys C,Chemerin,and Hcy levels in the NLVH and LVH groups were higher than those in the control group.The BMI,SBP,DBP,Cys C,Chemerin,and Hcy levels in the LVH group were higher than those in the NLVH group,and the differences were statistically significant(P<0.05).The number of smokers and Cr levels in the NLVH group were higher than those in the control group,and the differences were statistically significant.However,compared with the LVH group,the differences were not statistically significant.There was no statistically significant difference in age,gender,blood lipids,and other indicators among the three groups.There was no statistically significant difference in the course of disease and the use of antihypertensive drugs between the NLVH group and the LVH group.Cys C and Chemerin are positively correlated with the left ventricular mass index,with correlation coefficients of 0.305 and 0.182,respectively.Multivariate regression analysis showed that SBP,obesity,Cys C,C

关 键 词：胱抑素C 趋化素 高血压 左心室肥厚 

分 类 号：R54[医药卫生—心血管疾病]