肾上腺髓质素前体中段肽联合血清降钙素原在脓毒症诊疗中的应用  

The application of adrenomedullin precursor midbody peptide combined with serum calcitoninogen in the diagnosis and treatment of sepsis

作　　者：李卫兵[1] 丁好 桑玉玉[1] 薛漓 姚辉[2] Li Weibing;Ding Hao;Sang Yuyu(Laboratory,Nantong Traditional Chinese Medicine Hospital,Nantong 226001,China)

机构地区：[1]南通市中医院检验科,226001 [2]南通市妇幼保健院检验科

出　　处：《中华保健医学杂志》2024年第2期173-175,共3页Chinese Journal of Health Care and Medicine

基　　金：南通市市级科技计划项目(JCZ20002);南通市中医联盟课题立项项目(TZYK202205)。

摘　　要：目的分析肾上腺髓质素前体中段肽(MR-proADM)联合降钙素原(PCT)检测在脓毒症诊疗中的应用价值。方法回顾性选取2020年1月~2023年6月南通市中医院收治的45例脓毒症患者为脓毒症组,同期选取43例健康体检者为健康对照组。入组者均于入院24 h内检测血清MR-proADM、PCT水平,脓毒症组以是否为休克脓毒症分为休克组(20例)与非休克组(25例),以不同预后情况分为死亡组(5例)与存活组(40例)。比较健康对照组与脓毒症组MR-proADM、PCT水平,同时比较各亚组MR-proADM、PCT水平,并分析MR-proADM、PCT指标单一检测与联合检测对脓毒症的预测价值。结果脓毒症组MR-proADM、PCT水平较健康对照组更高,差异有统计学意义(t=83.306、35.745,P<0.05);休克组MR-proADM、PCT水平较非休克组更高,差异有统计学意义(t=24.867、2.149,P<0.05);死亡组MR-proADM、PCT水平较存活组更高,差异有统计学意义(t=15.458、2.174,P<0.05)。联合检测用于预测脓毒症的ROC曲线下面积(AUC)较MR-proADM、PCT单一检测更高(P<0.05)。结论MR-proADM联合PCT检测用于脓毒症诊疗,可为疾病诊治提供可靠依据,并可用于评估预后。Objective To analyze the application value of adrenomedullin precursor mid-peptide(MR-proADM)combined with calcitoninogen(PCT)test in the diagnosis and treatment of sepsis.Methods Forty-five sepsis patients admitted from January 2020 to June 2023 were selected as the sepsis group,and 43 healthy physical examiners were selected as the control group during the same period.Serum MR-proADM and PCT levels were measured within 24 h of admission for all those enrolled,and the sepsis group was divided into shock group(20 cases)and non-shock group(25 cases)according to whether they were shock sepsis,and into death group(5 cases)and survival group(40 cases)according to different prognosis.The MR-proADM and PCT levels in the control group were compared with those in the sepsis group,and the MR-proADM and PCT levels in each subgroup were also compared.The predictive value of MR-proADM and PCT indexes single test and combined test for sepsis were analyzed.Results MR-proADM and PCT levels were higher in the sepsis group compared with the control group(t=83.306,35.745,P<0.05).MR-proADM and PCT levels were higher in the shock group compared with the non-shock group(t=24.867,2.149,P<0.05).MR-proADM and PCT levels were higher in the death group compared with the survival group(t=15.458,2.174,P<0.05).The area under the ROC curve(AUC)of the combined assay for predicting sepsis was higher than The area under the ROC curve(AUC)of the combined assay for predicting sepsis was higher than that of the MR-proADM and PCT single assay(P<0.05).Conclusion MR-proADM combined with PCT assay for sepsis diagnosis and treatment can provide a reliable basis for disease diagnosis and treatment,and can be used to assess prognosis.

关 键 词：降钙素原 脓毒症 联合检测 肾上腺髓质素前体中段肽 诊断价值 

分 类 号：R631[医药卫生—外科学]