新型冠状病毒感染后不同年龄阶段患者新型冠状病毒总抗体水平调查分析  

Investigation and analysis of total antibody levels of novel coronavirus in different age stages after novel coronavirus infection

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作  者:王婷[1] 张丹[1] 李敏[2] Wang Ting;Zhang Dan;Li Min(Department of Geriatrics,Shaanxi Provincial People′s Hospital,Xi′an 710068,China)

机构地区:[1]陕西省人民医院老年病院西院一病区,西安710068 [2]陕西省人民医院老年病院保健办,西安710068

出  处:《中华保健医学杂志》2024年第2期180-182,共3页Chinese Journal of Health Care and Medicine

基  金:陕西省重点研发计划(2021SF-352、2022SF-059)。

摘  要:目的了解不同年龄阶段患者新型冠状病毒感染转阴后1~2月新型冠状病毒总抗体的水平。方法回顾性分析2023年2月~4月于陕西省人民医院门诊和体检中心行新型冠状病毒总抗体检测患者1009例。比较不同性别血清新型冠状病毒总抗体水平;比较≥65岁老年患者与<65岁患者血清新型冠状病毒总抗体水平;再依据年龄,将≥65岁老年患者分为3组(65岁≤A组<75岁,75≤B组<85岁,85岁≤C组),比较3组老年患者血清新型冠状病毒总抗体水平。对≥65岁老年患者年龄与新型冠状病毒总抗体水平行相关性分析。结果男性与女性患者血清新型冠状病毒总抗体水平[1430.43(148.95,1466.76)S Co vs.1023.62(97.79,1483.49)S Co]差异无统计学意义(Z=-0.66.74,P=0.51)。≥65岁老年患者新型冠状病毒总抗体水平较<65岁患者明显降低[886.36(47.25,1443.74)S Co vs.1139.24(262.02,1509.74)S Co],差异有统计学意义(Z=-3.93,P=0.00)。A组新型冠状病毒总抗体水平明显高于B、C组[1074.54(143.93,1485.32)S Co vs.448.42(38.05,1389.25)S Co;1074.54(143.93,1485.32)S Co vs.176.43(11.29,1258.94)S Co],差异有统计学意义(P=0.00)。B组和C组组间新型冠状病毒总抗体水平差异无统计学意义(P>0.05)。≥65岁老年患者年龄与新型冠状病毒总抗体水平呈负相关(r=-0.24,P=0.00)。结论老年患者,尤其高龄老年患者感染新型冠状病毒转阴后抗体水平偏低,临床医师应认识到老年人再感染风险,相关专家应考虑制定老年人专属的免疫预防方案。Objective To investigate the level of novel coronavirus total antibody in different age groups after novel coronavirus infection turned negative from 1 to 2 months.Methods 1009 Patients who underwent novel coronavirus total antibody detection in Shaanxi Provincial People′s hospital′s outpatient clinic or physical examination center from February 2023 to April 2023 were retrospectively analyzed.Comparing the total serum novel coronavirus antibody levels of different genders.Comparing the serum novel coronavirus total antibody levels of elderly patients aged 65 and above and adult patients under 65 years old.According to age,the participants were divided into 3 groups(65 age≤group A<75 years old,75≤group B<85 years old,85 years old≤group C),and compare the serum total antibody levels of novel coronavirus in each group.Correlation analysis between age and total antibody level of novel coronavirus in elderly patients aged 65 and over.Results There was no significant difference in serum total novel coronavirus antibody levels between male and female patients[1430.43(148.95,1466.76)S/Co vs.1023.62(97.79,1483.49)S/Co,Z=-0.66.74,P=0.51].The total antibody level of novel coronavirus in patients aged 65 and above was significantly lower than that in patients under 65 years old[886.36(47.25,1443.74)S/Co vs.1139.24(262.02,1509.74)S/Co,Z=-3.93,P=0.00].The level of total novel coronavirus antibody in group A was significantly higher than that in group B and C[1074.54(143.93,1485.32)S/Co vs.448.42(38.05,1389.25)S/Co;1074.54(143.93,1485.32)vs.176.43(11.29,1258.94),P=0.00];There was no statistical significance in the total antibody level of novel coronavirus between groups B and C(P=0.00).There was a significant negative correlation between age and total novel coronavirus antibody level in elderly patients aged 65 and above(r=-0.24,P=0.00).Conclusion Elderly patients,especially older elderly patients,have low antibody levels after infection with novel coronavirus and become harmful.Clinicians should be aware of the risk

关 键 词:新型冠状病毒 新型冠状病毒抗体 老年人 

分 类 号:R373.1[医药卫生—病原生物学]

 

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