基于数据挖掘探讨肖承悰治疗黄体功能不全性不孕的用药规律  

Exploration on Medication Law of Xiao Chengcong in Treating Luteal Phase Defect Infertility Based on Data Mining

作　　者：柯欣吟 汤玲[1] 肖承悰(指导)[1] KE Xinyin;TANG Ling;XIAO Chengcong(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中国中医药信息杂志》2024年第5期42-46,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：第四届国医大师传承工作室建设项目(401091401)。

摘　　要：目的利用数据挖掘技术分析肖承悰教授治疗黄体功能不全性不孕的用药规律,探讨其临证经验。方法收集2007年12月-2021年12月肖承悰教授门诊患者病历资料,筛选后录入FangNet平台,通过频次统计、协同性分级、药物-症状关联、药物聚类、性味归经等对用药规律进行分析。结果共纳入病案90则,涉及患者90例、处方270首。肖承悰教授治疗黄体功能不全性不孕高频药物包括桑寄生、续断、巴戟天、茯苓、女贞子等,药性多温、平,药味以甘为主,主归肾经、肝经。药物聚类分析显示,桑寄生、续断、巴戟天为主要药对。结论肖承悰教授认为,黄体功能不全性不孕的病机为肾阳亏虚,治以温肾助阳为主,兼以养肝健脾,调理冲任;用药强调药性平和,临床中擅用药对,展现了燕京萧氏妇科“和合灵动”的学术思想。Objective To analyze Professor Xiao Chengcong’s medication law in the treatment of luteal phase defect infertility using data mining technology;To discuss Professor Xiao Chengcong’s clinical experience.Methods The medical records of patients with luteal phase defect infertility who visited Professor Xiao Chengcong’s clinic from December,2007 to December,2021 were collected.The data were screened and entered into the FangNet Platform.Through frequency statistics,collaborative classification,drug-symptom association,drug clustering,property,taste and meridian,the medication law was analyzed.Results This study included 90 medical records,with 90 patients and 270 prescriptions.The most frequently used drugs for luteal phase defect infertility were Taxilii Herba,Dipsaci Radix,Morinda Officinalis Radix,Poria,and Ligustri Lucidi Fructus,etc.;the properties were mainly warm and mild;the mainly taste was sweet;the main meridians were kidney meridian and liver meridian.The drug cluster analysis showed that the main drug pairs were Taxilli Herba,Dipsaci Radix,Morindae Officinalis Radix.Conclusion Professor Xiao Chengcong believes that the pathogenesis of luteal phase defect infertility is deficiency of kidney-yang;therefore,the treatment should mainly focus on tonifying the kidney to support yang,with nourishing the liver,strengthening the spleen,and regulating the Chong and Ren meridians.Medication emphasis the drugs with mild property and medicinal pairs in clinic,showing the academic thought of“harmony and flexibility”of Xiao’s gynecology department in Yanjing.

关 键 词：不孕症 黄体功能不全 数据挖掘 肖承悰 用药规律 

分 类 号：R2-05[医药卫生—中医学] R271.14