血液病患者血清抗弓形虫抗体调查  

Seroprevalence of the specific antibody against Toxoplasma gondii among patients with hematological diseases

作　　者：甘东辉 范金清 曾锦芳 林君 陈晓君 GAN Donghui;FAN Jinqing;ZENG Jinfang;LIN Jun;CHEN Xiaojun(Department of Hematology,The Affiliated Hospital of Putian University,Putian,Fujian 351100,China;Department of Clinical Laboratory,The Affiliated Hospital of Putian University,China)

机构地区：[1]莆田学院附属医院血液内科,福建莆田351100 [2]莆田学院附属医院检验科

出　　处：《中国血吸虫病防治杂志》2024年第1期83-86,共4页Chinese Journal of Schistosomiasis Control

基　　金：福建省自然科学基金项目(2022J011444);莆田学院科研基金项目(2021030)。

摘　　要：目的调查血液病患者弓形虫感染血清学阳性率,为改善血液病患者预后、提高患者生活质量提供借鉴。方法以2021年1月1日—2023年10月10日在莆田学院附属医院就诊的240例血液病患者(血液系统肿瘤性疾病患者170例、血液系统非肿瘤性疾病患者70例)和同期在该院体检的500例健康体检者为研究对象。收集研究对象人口学特征和血清样本,采用化学发光法检测血清抗弓形虫IgG和IgM抗体,以IgG或IgM抗体任一阳性视为抗体阳性,对血液病患者和健康体检者血清抗弓形虫IgG和IgM抗体阳性率进行比较。结果血液系统肿瘤性疾病患者、血液系统非肿瘤性疾病患者和健康体检者平均年龄(F=2.034,P>0.05)和性别构成差异均无统计学意义(χ^(2)=0.462,P>0.05),血液病患者与健康体检者有猫或犬接触史比例差异无统计学意义(χ^(2)=0,P>0.05)。血液病患者血清抗弓形虫抗体阳性率显著高于健康体检者(15.8%vs.0.6%;χ^(2)=71.902,P<0.01),血液系统肿瘤性疾病(18.2%)、血液系统非肿瘤性疾病患者(10.0%)及健康体检者血清抗弓形虫抗体阳性率差异有统计学意义(χ^(2)=78.327,P<0.01);两两比较发现,血液系统肿瘤性疾病、血液系统非肿瘤性疾病患者血清抗弓形虫抗体阳性率均显著高于健康体检者(P均<0.05),而血液系统肿瘤性疾病与非肿瘤性疾病患者血清抗弓形虫抗体阳性率差异无统计意义(P>0.05)。血清抗弓形虫抗体阳性的血液病患者有猫或犬接触史比例显著高于血清抗弓形虫抗体阴性的血液病患者(21.1%vs.5.4%;χ^(2)=8.653,P<0.05)。结论血液病患者弓形虫感染血清学阳性率较高,且显著高于健康体检者。Objective To investigate the seroprevalence of Toxoplasma gondii infections among patients with hematological diseases,so as to provide insights into improving the prognosis and quality of life among patients with hematological diseases.Methods A total of 240 patients with hematological diseases(including 170 patients with hematological tumors and 70 patients with non-tumor hematological diseases)admitted to The Affiliated Hospital of Putian University during the period from January 1,2021 through October 10,2023 and 500 healthy volunteers in the hospital during the same period were enrolled.Subjects’demographics and serum samples were collected,and serum specific IgG and IgM antibodies against T.gondii were detected using the chemiluminescence assay,with any of a positive IgG or IgM antibody defined as a positive T.gondii infection.The seroprevalence of specific IgG and IgM antibodies against T.gondii was compared between patients with hematological diseases and healthy volunteers.Results The mean age(F=2.034,P>0.05)and gender distribution(χ^(2)=0.462,P>0.05)were comparable among patients with hematological tumors,patients with non-tumor hematological diseases and healthy volunteers,and there was no significant difference in the proportion of history of cat or dog contacts between patients with hematological diseases and healthy volunteers(χ^(2)=0,P>0.05).The seroprevalence of anti-T.gondii antibody was significantly higher among patients with hematological diseases than among healthy volunteers(15.8%vs.0.6%;χ^(2)=71.902,P<0.01),and there was a significant difference in the seroprevalence of anti-T.gondii antibody among patients with hematological tumors(18.2%),patients with non-tumor hematological diseases(10.0%)and healthy volunteers(χ^(2)=78.327,P<0.01).The seroprevalence of anti-T.gondii antibody was significantly higher among patients with hematological tumors and non-tumor hematological diseases than among healthy volunteers(both P values<0.05),while no significant difference was seen in the seroprev

关 键 词：刚地弓形虫 血清阳性率 血液病 

分 类 号：R382.5[医药卫生—医学寄生虫学]