寄生虫抗癌症作用及其机制研究进展  

Anticancer effects of parasites and its underlying mechanisms:a review

作　　者：张莹舒 丁昕 戴洋 ZHANG Yingshu;DING Xin;DAI Yang(School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;National Health Commission Key Laboratory of Parasitic Disease Prevention and Control,Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology,Jiangsu Provincial Medical Key Laboratory,Jiangsu Institute of Parasitic Diseases,Wuxi,Jiangsu 214064,China)

机构地区：[1]南京医科大学公共卫生学院,江苏南京211166 [2]国家卫生健康委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省医学重点实验室、江苏省血吸虫病防治研究所,江苏无锡214064

出　　处：《中国血吸虫病防治杂志》2024年第1期91-97,共7页Chinese Journal of Schistosomiasis Control

基　　金：江苏省科教能力提升工程(ZDXYS202207)。

摘　　要：寄生虫病和癌症均为严重危害人类健康的疾病。近年来研究发现,寄生虫感染与肿瘤间关系密切,多种寄生虫感染及其来源产物能够抑制癌症发生、发展与转移,显示了较好抗癌症潜能。因此,充分解析寄生虫、癌症与宿主间的相互作用,不仅可以为癌症治疗领域研究开拓新的思路,而且可为寄生虫来源抗癌症活性分子筛选奠定基础。本文围绕寄生虫的抗癌症效应及其潜在机制等方面的最新研究进展作一综述。Both parasitic diseases and cancers are disorders that seriously threaten human health.A strong correlation has been recently found between parasitic infections and cancers,and multiple species of parasites and their derived products have shown effective to suppress cancer development,progression and metastasis.Therefore,deciphering the interaction among parasites,cancers and hosts not only provides new insights into the development of cancer therapy,but also provides the basis for screening of parasites-derived active anticancer molecules.This review summarizes the latest advances in the anticancer activity of parasites and underlying mechanisms.

关 键 词：寄生虫 癌症 宿主 抗癌作用 分子机制 

分 类 号：R53[医药卫生—内科学]