真实世界氯硝西泮超适应症使用影响因素分析  

Analysis of influencing factors of off-label indication use of clonazepam in real world

作　　者：章袁[1] 王超[1] 朱静[1] 常斌鸽[1] Zhang Yuan;Wang Chao;Zhu Jing;Chang Binge(Tianjin First Central Hospital,Tianjin 300191)

机构地区：[1]天津市第一中心医院,天津300191

出　　处：《天津药学》2024年第2期25-29,共5页Tianjin Pharmacy

基　　金：天津药学中青年科研项目(No.TJYX2023-06)。

摘　　要：目的:探讨真实世界中氯硝西泮超适应症使用的影响因素。方法:回顾性分析2020年1月—2022年12月本院门诊使用氯硝西泮的患者1291例,并收集患者基本信息,Logistic回归分析氯硝西泮超适应症的影响因素。结果:非超适应症组97例,超适应症组1194例,超适应症类型主要为睡眠障碍、焦虑症和抑郁症。Logistic回归分析显示,接诊医师级别(OR=2.721,95%CI:1.757~4.212,P<0.05)、患者医保类型(OR=0.394,95%CI:0.203~0.766,P<0.001)是影响氯硝西泮超适应症的独立危险因素。结论:氯硝西泮在门诊患者中使用的超适应症主要为睡眠障碍、焦虑和抑郁症,患者医保类型、接诊医师级别与氯硝西泮超适应症使用有显著相关性。Objective:To explore the influencing factors of off-label indication use of clonazepam in real world.Methods:1291outpatients using clonazepam in outpatient department from January 2020 to December 2022 were retrospectively analyzed,and the basic information of patients was collected.The influencing factors of off-label indication use of clonazepam in the outpatient department were analyzed by Logistic regression.Results:There were 97cases in the non offlabel indication group and 1194 cases in the off-label indication group.The main off-label indications were sleep disorders,anxiety and depression.Multivariate Logistic regression analysis showed that the level of attending physician(OR=2.771,95%CI:1757~4.212,P<0.05)and the type of medical insurance(OR=0.394,95%CI:0.203~0.766,P<0.001)were independent risk factors for off-label indication of clonazepam.Conclusion:The main off-label indication of clonazepam in outpatients are sleep disorders,anxiety and depression.The type of medical insurance and the level of attending physician were significantly correlated with off-label indication use of clonazepam.

关 键 词：氯硝西泮 超说明书用药 真实世界 影响因素 

分 类 号：R969.3[医药卫生—药理学]