烧伤伤员胃肠道屏障损伤机制与治疗药物的研究进展  

Research Progress in Mechanism of Gastrointestinal Barrier Injury and Therapeutic Drugs in Burn Patients

作　　者：徐向迎 连锦 熊新娟 宗晶 王小洁 XU Xiang-ying;LIAN Jin;XIONG Xin-juan;ZONG Jing;WANG Xiao-jie(The 960th Hospital of Joint Logistic Support Force of PLA,Jinan 250031,China)

机构地区：[1]联勤保障部队第960医院,山东济南250031

出　　处：《解放军药学学报》2024年第2期185-188,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：联勤保障部队军队护理创新与培育专项计划,No.2021HL068。

摘　　要：烧伤休克伤员的救治是医学救援的重要工作之一。烧伤后胃肠道屏障损伤机制仍不明确,胃肠道血流量、胃酸分泌、再灌注损伤等因素都被证实与其有关。目前烧伤后胃肠道屏障损伤的主要治疗药物包括抗生素、谷氨酰胺、整蛋白型肠内营养剂等,但治疗效果并不理想。为提高烧伤的救治水平,本文对烧伤伤员胃肠道屏障损伤的机制、主要药物及新兴疗法进展作一综述。The treatment of burn shock patients is one of the important tasks for medical rescuers.The mechanism of gastrointestinal barrier injury after burn remains unclear.Gastrointestinal blood flow,gastric acid secretion,reperfusion injury and other factors have been confirmed to be involved.The main therapeutic drugs for gastrointestinal barrier injury after burn include antibiotics,glutamine and whole protein enteral nutrition,but the therapeutic effect is far from satisfactory.With growing research,new promising treatment options have gradually emerged.In order to treat burns more effectively,this paper reviews the mechanism,main drugs and emerging therapies of gastrointestinal barrier injury in burn patients.

关 键 词：烧伤 胃肠道屏障损伤 临床用药 

分 类 号：R975[医药卫生—药品]