肠道细菌介导中药代谢的研究概述  

Overview of research on intestinal flora mediating the metabolism of Chinese medicine

作　　者：郭俊杰 秦雪梅[1,2,3] 刘月涛[1,2,3] GUO Jun-jie;QIN Xue-mei;LIU Yue-tao(Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China;Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM,Shanxi University,Taiyuan 030006,China)

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]山西大学化学化工学院,山西大学化学生物学与分子工程教育部重点实验室,山西太原030006 [3]山西大学,地产中药功效物质研究与利用山西省重点实验室,山西太原030006

出　　处：《药学学报》2024年第4期831-839,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金面上项目(82073988,82374025)。

摘　　要：人体肠道中栖息着数量庞大、种类繁多的微生物,这些微生物与其所寄居的肠道环境组成了肠道微生态系统。中药经口服后在胃肠道中被肠道微生物代谢,其代谢产物吸收入血从而产生药理作用。本文就肠道菌群介导中药代谢的特点和影响因素进行综述,同时归纳了近年来肠道细菌介导黄酮类、皂苷类、环烯醚萜类、木脂素类等中药成分代谢的研究进展,为阐明肠道细菌与中药成分化学结构变化之间的关系、肠道细菌代谢中药成分的规律与机制研究提供依据。The human gut is inhabited by a large number and variety of microorganisms,which constitute the intestinal microecosystem with the intestinal environment where they reside.After oral administration,Chinese medicine undergoes metabolism by these intestinal microorganisms within the gastrointestinal tract.The resulting metabolites are absorbed into the bloodstream to produce pharmacological effects.This paper provides a comprehensive review of the characteristics and influencing factors related to the mediation of Traditional Chinese Medicine(TCM)metabolism by intestinal flora.Additionally,recent progress in the microbial-mediated metabolism of TCM components such as flavonoids,saponins,iridoids,and lignans is summarized.This serves as a foundation for understanding the connection between intestinal bacteria and the chemical structural alterations of TCM components.It also offers insight into the regulations and mechanisms governing the intestinal bacterial metabolism of TCM constituents.

关 键 词：肠道菌群 中药 代谢特点 影响因素 有效成分 

分 类 号：R917[医药卫生—药物分析学]