中药抗肿瘤明星分子无载体和有载体超分子纳米体系研究进展  

Research progress on carrier-free and carrier-supported supramolecular nanosystems of traditional Chinese medicine anti-tumor star molecules

作　　者：臧子叶 张瑶芝 赵一航 谭心如 魏吉昌 徐安琪 段鸿飞 张红妍 王鹏龙[1] 黄雪梅 雷海民[1] ZANG Zi-ye;ZHANG Yao-zhi;ZHAO Yi-hang;TAN Xin-ru;WEI Ji-chang;XU An-qi;DUAN Hong-fei;ZHANG Hong-yan;WANG Peng-long;HUANG Xue-mei;LEI Hai-min(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《药学学报》2024年第4期908-917,共10页Acta Pharmaceutica Sinica

基　　金：中央高校基金科研业务项目(2023-JYB-JBZD-049,2022-XJ-KYQD-008,S202310026034);国家自然科学基金资助项目(82274072).

摘　　要：抗肿瘤中药具有悠久的临床应用史,其中的明星分子一直是现代药物研究的热点,但受限于中药单体成分溶解性、稳定性、靶向性、生物活性或毒性等成药性问题,阻碍了中药抗肿瘤明星分子进一步临床转化应用。当前,通过分子自组装、纳米材料包载等技术制备的纳米体系在改善中药活性成分抗肿瘤方面具有广阔的应用前景,引起了国内外学者的广泛关注。本文系统概述了将中药抗肿瘤明星分子制备成超分子纳米体系的研究进展,总结了目前报道的无载体和有载体两大类、10小类超分子纳米体系及其研究案例,并对未来发展方向提出展望,旨在为使用超分子技术改善中药抗肿瘤明星分子临床应用的研究及临床转化提供参考。Anti-tumor traditional Chinese medicine has a long history of clinic application,in which the star molecules have always been the hotspot of modern drug research,but they are limited by the solubility,stability,targeting,bioactivity or toxicity of the monomer components of traditional Chinese medicine anti-tumor star molecules and other pharmacokinetic problems,which hinders the traditional Chinese medicine anti-tumor star molecules for further clinical translation and application.Currently,the nanosystems prepared by supramolecular technologies such as molecular self-assembly and nanomaterial encapsulation have broader application prospects in improving the anti-tumor effect of active components of traditional Chinese medicine,which has attracted extensive attention from scholars at home and abroad.In this paper,we systematically review the research progress in preparation of supramolecular nano-systems from anti-tumor star molecule of traditional Chinese medicine,and summarize the two major categories and ten small classes of carrier-free and carrier-based supramolecular nanosystems and their research cases,and the future development direction is put forward.The purpose of this paper is to provide reference for the research and clinical transformation of using supramolecular technology to improve the clinical application of anti-tumor star molecule of traditional Chinese medicine.

关 键 词：抗肿瘤 超分子 无载体 有载体 中药明星分子 

分 类 号：R943[医药卫生—药剂学]