猪繁殖与呼吸综合征病毒NSP2基因研究进展  

Research Progress on NSP2 Gene of Porcine Reproductive and Respiratory Syndrome Virus

作　　者：张航 沙惠阳 黄良宗 赵孟孟 ZHANG Hang;SHA Huiyang;HUANG Liangzong;ZHAO Mengmeng(College of Life Science and Engineering,Foshan University,Foshan 528231,China;College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450002,China)

机构地区：[1]佛山科学技术学院生命科学与工程学院,佛山528231 [2]河南农业大学动物医学院,郑州450002

出　　处：《中国动物传染病学报》2024年第1期214-221,共8页Chinese Journal of Animal Infectious Diseases

基　　金：国家自然科学基金项目(31902279)。

摘　　要：猪繁殖与呼吸综合征是由猪繁殖与呼吸综合征病毒(PRRSV)引起的一种烈性传染病。PRRSV的非结构蛋白2(NSP2)编码一个多功能蛋白,具有广泛生物学作用。本文对NSP2遗传变异分析,与自身病毒蛋白互作,与宿主蛋白互作,影响PRRSV复制、毒力、细胞噬性,调节宿主免疫以及在疫苗应用等相关研究进行综述,为深入研究PRRSV致病机理和疫苗设计提供重要理论基础。Porcine reproductive and respiratory syndrome is a severe infectious disease caused by Porcine reproductive and respiratory syndrome virus(PRRSV).Non-structural protein 2(NSP2)encodes a multifunction protein that has a wide range of biological effects.This paper reviews NSP2 genetic variation,interactions with its own proteins and host proteins,effects on virus replication,toxicity,cell phagocytosis,regulation of host immunity and application in vaccine research and provides an important theoretical basis for further study of PRRSV pathogenic mechanism and vaccine design.

关 键 词：猪繁殖与呼吸综合征病毒 NSP2基因 致病机理 疫苗研究 

分 类 号：S852.651[农业科学—基础兽医学]