水飞蓟宾联合多烯磷脂酰胆碱在活动性肺结核患者化疗中的肝保护作用  

Hepatoprotective Effect of Silibinin Combined with Polyene Phosphatidylcholine in Chemotherapy of Active Pulmonary Tuberculosis Patients

作　　者：王文夫 WANG Wenfu(The First Tuberculosis Ward of Respiratory Department,Fuxin Infectious Disease Hospital,Fuxin 123000,Liaoning Province,China)

机构地区：[1]阜新市传染病医院呼吸科结核一病房,辽宁阜新123000

出　　处：《中国实用乡村医生杂志》2024年第3期12-15,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨水飞蓟宾联合多烯磷脂酰胆碱在活动性肺结核(active pulmonary tuberculosis,APT)患者化疗过程中的肝保护作用。方法选择2020年1月—2022年12月阜新市传染病医院收治的APT患者50例,随机分为对照组和观察组各25例。两组患者均在化疗过程中接受保肝治疗,对照组用药为多烯磷脂酰胆碱,观察组在此基础上加用水飞蓟宾。比较两组患者治疗3个月后的肝功能、炎症因子和氧化应激指标。结果治疗后,观察组丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素、γ-谷氨酰转肽酶、碱性磷酸酶、肿瘤坏死因子-α、白介素-1β、白介素-2、白介素-6、白介素-17、丙二醛、一氧化氮水平低于对照组,差异有统计学意义(P<0.05);而超氧化物歧化酶、还原型谷胱甘肽、铜蓝蛋白水平高于对照组,差异有统计学意义(P<0.05)。结论水飞蓟宾联合多烯磷脂酰胆碱可以强化肝脏保护作用,这一机制可能与调节氧化应激和炎症反应有关。Objective To explore the hepatoprotective effect of silibinin combined with polyene phosphatidylcholine during chemotherapy in patients with active pulmonary tuberculosis(APT).Methods Fifty APT patients admitted to Fuxin Infectious Disease Hospital from January 2020 to December 2022 were randomly divided into a control group and an observation group,with 25 cases in each group.Both groups of patients received liver protection treatment during chemotherapy.The control group was treated with polyene phosphatidylcholine.The observation group added silibinin on this basis.The indicators of liver function,inflammatory factors,and oxidative stress in two groups were compared after 3 months of treatment.Results After treatment,the levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin gamma-glutamyl transferase,alkaline phosphatase,tumor necrosis factor-α,interleukin-1β,interleukin-2,interleukin-6,interleukin-17,malondialdehyde,and nitric oxide in the observation group were significantly lower than those in the control group(P<0.05).The levels of superoxide dismutase,reduced glutathione and ceruloplasmin in the observation group were significantly higher than those in the control group(P<0.05).Conclusion The combination of silibinin and polyene phosphatidylcholine can enhance liver protection,which may be related to regulating oxidative stress and inflammatory response.

关 键 词：肺结核 活动性 水飞蓟宾 多烯磷脂酰胆碱 化疗 肝损害 

分 类 号：R521.1[医药卫生—内科学]