MAGiC技术诊断新生儿高胆红素血症  

MAGiC technique for diagnosing neonatal hyperbilirubinemia

作　　者：刘畅 闫瑞芳[1] 谢北辰 任继鹏[1] 段金辉 崔静威 翟晓阳 LIU Chang;YAN Ruifang;XIE Beichen;REN Jipeng;DUAN Jinhui;CUI Jingwei;ZHAI Xiaoyang(Department of Magnetic Resonance,The First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院磁共振科,河南新乡453100

出　　处：《中国医学影像技术》2024年第4期508-513,共6页Chinese Journal of Medical Imaging Technology

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20230505);2023年度新乡市市级重点实验室认定名单(新乡市新生儿神经系统疾病影像研究重点实验室)。

摘　　要：目的 观察MAGiC技术诊断新生儿高胆红素血症(NHB)的价值。方法 前瞻性纳入33例NHB新生儿作为NHB组,以30名正常新生儿为对照组;行MAGiC序列颅脑MR扫描,记录苍白球、壳核及丘脑ROI定量值,包括T1、T2弛豫值及质子密度(PD)值,并计算苍白球/壳核定量比值。比较组间各脑区定量值及定量比值,绘制受试者工作特征曲线,计算曲线下面积(AUC)以评估诊断效能,并以Pearson相关性分析评估血清总胆红素(TSB)水平与各脑区定量值及定量比值的相关性。结果 组间各脑区T1、T2及PD值差异均无统计学意义(P均>0.05);NHB组苍白球/壳核T1值比值、T2值比值均小于对照组(P均<0.05)。苍白球/壳核T1值比值诊断NHB的AUC为0.79(P<0.05);而苍白球/壳核T2值比值诊断NHB的效能低(AUC=0.63,P>0.05)。TSB与苍白球T2值(r=-0.299,P<0.05)、苍白球/壳核T1值比值(r=-0.480,P<0.05)及苍白球/壳核T2值比值(r=-0.328,P<0.05)均呈负相关。结论 以MAGiC技术获取苍白球/壳核T1值比值对于诊断NHB具有一定价值。Objective To observe the value of MAGiC technique for diagnosing neonatal hyperbilirubinemia(NHB).Methods Thirty-three newborns with NHB were prospectively enrolled as NHB group,while 30 healthy newborns were taken as control group.Brain MAGiC MRI were acquired.The quantitative values,including T1,T2 and proton density(PD)values in ROI of the globus pallidus,putamen,and thalamus were recorded,and the ratio of globus pallidus/putamen were calculated.The outcomes in each brain region were compared between groups.Receiver operating characteristic curves were drawn,the areas under the curve(AUC)were calculated to assess diagnostic efficacies,and Pearson analysis were performed to explore correlations of total serum bilirubin(TSB)level with the above quantitative values and quantitative ratios in each brain region.Results No significant difference of T1,T2 nor PD value of each brain region was observed between groups(all P>0.05),while globus pallidus/putamen T1 ratio and T2 ratio in NHB group were both smaller than those in control group(both P<0.05).AUC of globus pallidus/putamen T1 ratio for diagnosing NHB was 0.79(P<0.05),and efficacy of globus pallidus/putamen T2 ratio for diagnosing NHB was insufficient(AUC=0.63,P>0.05).Negative correlations were observed between TSB and globus pallidus T2 value(r=-0.299,P<0.05),between TSB and the globus pallidus/putamen T1 ratio(r=-0.480,P<0.05),also between TSB and the globus pallidus/putamen T2 ratio(r=-0.328,P<0.05).Conclusion Using MAGiC technology to obtain globus pallidus/putamen T1 ratio was valuable for diagnosis of NHB.

关 键 词：高胆红素血症 新生儿 回波平面成像 

分 类 号：R722.17[医药卫生—儿科] R445.2[医药卫生—临床医学]