5-氨基酮戊酸光动力学疗法联合干扰素栓对持续高危型人乳头瘤病毒感染患者病毒清除率及阴道微环境的影响  

Effect of 5-aminolevulinic acid photodynamic therapy combined with interferon suppository on virus clearance rate and vaginal microenvironment in patients with persistent high-risk human papilloma virus infection

作　　者：唐容迪 倪泞 沈菲 TANG Rongdi;NI Ning;SHEN Fei(Department of Obstetrics,Jingdezhen NO.1 People's Hospital,Jiangxi Province,Jingdezhen 333000,China)

机构地区：[1]江西省景德镇市第一人民医院产科,江西景德镇333000

出　　处：《中国当代医药》2024年第12期108-111,116,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(20204340)。

摘　　要：目的探究5-氨基酮戊酸光动力学疗法(ALA-PDT)联合干扰素栓对持续高危型人乳头瘤病毒(HPV)感染患者HPV清除率及阴道微环境的影响。方法选取2020年1月至2023年1月景德镇市第一人民医院收治的80例持续高危型HPV感染患者作为研究对象,采用随机数字表法将其分为对照组和观察组各40例,对照组采用干扰素栓治疗,观察组采用干扰素栓联合ALA-PDT治疗,观察两组病毒载量变化和HPV清除率、菌群密集度、菌群多样性、优势菌情况、阴道pH变化、Nugnet评分变化以及6个月内复发率。结果观察组治疗后的病毒载量低于对照组,HPV清除率高于对照组,差异有统计学意义(P<0.05);观察组治疗后的菌群密集度正常率、菌群多样性正常率、优势菌群健康率均高于对照组,差异有统计学意义(P<0.05);观察组治疗后的阴道pH、Nugnet评分均低于对照组,差异有统计学意义(P<0.05);观察组6个月内复发率低于对照组,差异有统计学意义(P<0.05)。结论ALA-PDT联合干扰素栓治疗持续高危型HPV感染患者可以提高HPV清除率,改善阴道微环境,降低复发率。Objective To explore the effect of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)combined with interferon suppository on clearance rate of human papilloma virus(HPV)and vaginal microenvironment in patients with persistent high-risk HPV infection.Methods A total of 80 patients with persistent high-risk HPV infection in Jingdezhen NO.1 People's Hospital were enrolled as the research objects from January 2020 to January 2023.According to random number table method,they were divided into control group and observation group,with 40 cases in each group.The control group was treated with interferon suppository,and the observation group was treated with interferon suppository combined with ALA-PDT.The changes in viral load,HPV clearance rate,density and diversity of floras,dominant bacteria,vaginal pH,Nugnet scores,and recurrence rate within 6 months in both groups were observed.Results After treatment,viral load in observation group was lower than that in control group,and HPV clearance rate was higher than that in control group,with statistically significant differences(P<0.05).After treatment,the normal rate of flora density,the normal rate of flora diversity,and the health rate of dominant flora in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the vaginal pH and Nugnet score in observation group were lower than those in control group,with statistically significant differences(P<0.05).The recurrence rate within 6 months in observation group was lower than that in control group,with a statistically significant difference(P<0.05).Conclusion ALA-PDT combined with interferon suppository can increase HPV clearance rate,improve vaginal microenvironment and reduce recurrence rate in patients with persistent high-risk HPV infection.

关 键 词：人乳头瘤病毒 持续高危型 5-氨基酮戊酸光动力学疗法 清除率 阴道微环境 

分 类 号：R373.9[医药卫生—病原生物学]