自拟中药“痹症1号”熏蒸方治疗早期轻中度类风湿关节炎患者的效果  

Effect of self-made"Bi Zheng No.1"Fumigation Prescription on early mild and moderate rheumatoid arthritis patients

作　　者：戴冰冰[1] 金香花[1] 张金涛[1] 张奎军[1] 许萍[1] 刘佳丽 梁丽君[1] 李英梅[1] DAI Bingbing;JIN Xianghua;ZHANG Jintao;ZHANG Kuijun;XU Ping;LIU Jiali;LIANG Lijun;LI Yingmei(Department of Rheumatology and Immunology,Dalian Municipal Central Hospital,Liaoning Province,Dalian 116033,China)

机构地区：[1]大连市中心医院风湿免疫科,辽宁大连116033

出　　处：《中国当代医药》2024年第12期125-130,共6页China Modern Medicine

基　　金：辽宁省大连市中医药科学研究计划项目(21Z11007)。

摘　　要：目的观察自拟中药“痹症1号”熏蒸方联合西药治疗早期轻中度类风湿关节炎患者的临床效果。方法选取2021年1月1日至2022年12月31日大连市中心医院风湿免疫科收治的140例早期轻中度类风湿关节炎患者作为研究对象,按照随机数字表法分为熏蒸组(70例)和非熏蒸组(70例),熏蒸组采用“痹症1号”熏蒸方联合常规西药治疗,非熏蒸组采用常规西药治疗。比较两组的治疗前后临床指标如关节症状、体征、晨僵时间、视觉模拟评分法(VAS)评分,健康状况评定量表(HAQ)、健康调查简表(SF-36)。检测两组患者的类风湿因子(RF)、红细胞沉降率(ESR)、C-反应蛋白(CRP)、白介素-1(IL-1)、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)、白介素-10(IL-10)、手关节超声评分、28个关节疾病活动评分(DAS 28)、简化疾病活动指数(SDAI)、临床疾病活动指数(CDAI)等指标。结果熏蒸组治疗12周的压痛关节数(TJC)、肿胀关节数(SJC)、手关节超声评分均低于非熏蒸组,差异有统计学意义(P<0.05)。熏蒸组治疗4、12周的VAS评分、HAQ评分、DAS 28评分均低于非熏蒸组,SF-36评分均高于非熏蒸组,差异有统计学意义(P<0.05);熏蒸组治疗12周的SDAI、CDAI均低于非熏蒸组,差异有统计学意义(P<0.05)。熏蒸组治疗12周的CRP低于非熏蒸组,差异有统计学意义(P<0.05)。两组患者治疗前及治疗4、8周的RF、IL-1、IL-6、TNF-α、IL-4、IL-10组间及组内比较,差异无统计学意义(P>0.05)。熏蒸组的总有效率高于非熏蒸组,差异有统计学意义(P<0.05)。结论“痹症1号”熏蒸方治疗早期轻中度类风湿关节炎临床疗效显著,具有明显的抗炎消肿及镇痛作用。Objective To observe the clinical effect of self-made"Bi Zheng No.1"Fumigation Prescription combined with western medicine on early mild and moderate rheumatoid arthritis patients.Methods A total of 140 patients with early mild to moderate rheumatoid arthritis treated in the Department of Rheumatology and Immunology,Dalian Municipal Central Hospital from January 1,2021 to December 31,2022 were selected as the research subjects.They were divided into fumigation group(70 cases)and non-fumigation group(70 cases)according to random number table method.The fumigation group was treated with the"Bi Zheng No.1"Fumigation Prescription combined with conventional western medicine,while the non-fumigation group was treated with conventional western medicine.The clinical indicators such as joint symptoms,signs,morning stiffness time,visual analogue scale(VAS)score,health assessment questionnaire(HAQ)and the medical outcomes study 36-item short form health survey(SF-36)were compared between the two groups before and after treatment.Rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),interleukin-10(IL-10),hand joint ultrasound score,disease activity score 28(DAS 28),simplified disease activity index(SDAI),clinical disease activity index(CDAI)and other indicators were detected in the two groups.Results After 12 weeks of treatment,the tender joint counts(TJC),swollen joint counts(SJC),and hand joint ultrasound scores of the fumigation group were lower than those of the non-fumigation group,and the differences were statistically significant(P<0.05).After 4 and 12 weeks of treatment,the VAS score,HAQ score and DAS 28 score of the fumigation group were lower than those of the non-fumigation group,and the SF-36 score was higher than that of the non-fumigation group,and the differences were statistically significant(P<0.05).The SDAI and CDAI of the fumigation group were lower than those of the non-fumigation group

关 键 词：类风湿关节炎 西药 中草药 中药熏蒸 

分 类 号：R593.22[医药卫生—内科学]