骨骼肌缺血再灌注损伤后对降钙素原及白细胞介素-6水平的影响  

Effects of skeletal muscle ischemia-reperfusion injury on procalcitonin and interleukin-6 levels

作　　者：嵇晓霞[1] 任志明[2] JI Xiaoxia;REN Zhiming(Depatment of Clinical Laboratory,the Third Affiliated Hospital of Baotou Medical College/National Medicine Northern Hospital,Baotou,Inner Mongolia,014030,China;Department of Anesthesiology,the Fourth Hospital of Baotou,Baotou,Inner Mongolia,014030,China)

机构地区：[1]包头医学院第三附属医院/国药北方医院检验科,内蒙古包头014030 [2]包头市第四医院麻醉科,内蒙古包头014030

出　　处：《当代医学》2023年第30期41-44,共4页Contemporary Medicine

摘　　要：目的探讨骨骼肌缺血再灌注损伤后对降钙素原(PCT)、白细胞介素-6(IL-6)水平的影响。方法选取2020年6月至2021年6月于国药北方医院择期行单侧下肢骨折术后内固定物取出术的60例患者作为研究对象,随机分为A组与B组,每组30例。A组实施单侧下肢骨折术后内固定物取出术,术中均持续输入0.9%氯化钠注射液,B组在A组基础上采用止血带扎于大腿中上1/3处。比较两组不同时间体温、平均动脉压(MAP)、心率(HR)和PCT、IL-6水平及术后48h内感染情况。结果T_(3)时,A组HR高于T_(1),MAP高于T_(2),且B组MAP高于T_(1)、T_(2),差异有统计学意义(P<0.05),两组组内其他时间点两两比较差异无统计学意义;T_(3)时,A组HR高于B组,差异有统计学意义(P<0.05),两组其他时间点各指标两两比较差异无统计学意义。T_(2)、T_(3)时,两组术后各时间点PCT、IL-6水平均高于前一时间点,差异有统计学意义(P<0.05)。T_(1)时,两组PCT、IL-6水平比较差异无统计学意义;T_(2)、T_(3)时,B组PCT、IL-6水平均高于A组,差异有统计学意义(P<0.05)。两组感染率比较差异无统计学意义。结论骨骼肌的缺血再灌注损伤可造成PCT及IL-6水平升高,可帮助预判患者病情严重程度及感染情况,但在临床实际应用中应考虑其干扰他因素,使其预测效果更加准确。Objective To investigate the effects of skeletal muscle ischemia-reperfusion injury on procalcitonin(PCT)and interleukin-6(IL-6)levels.Methods 60 patients who underwent internal fixation extraction after unilateral lower limb fracture in National Medicine Northern Hospital from June 2020 to June 2021 were selected as the study subjects,and they randomly divided into the group A and the group B,with 30 cases in each group.The group A were treated with internal fixation removal after unilateral lower limb fracture surgery,and 0.9%sodium chloride injection was continuously infused during the operation,the group B was treated with tourniquet at the middle and upper 1/3 of the thigh on the basis of group A,the body temperature,mean arterial pressure(MAP),heart rate(HR),PCT and IL-6 levels at different time points and infection within 48 h after oper-ation were compared between the two groups.Results At T_(3),HR in the group A was higher than that at T_(1),MAP was higher than that at T_(2),and MAP in the group B was higher than that at T_(1) and T_(2),the differences were statistically significant(P<0.05),there was no significant difference be-tween the two groups at other time points;At T_(3),HR in the group A was higher than that in the group B,and the difference was statistically signifi-cant(P<0.05),there was no significant difference between the two groups at other time points.At T_(2) and T_(3),the levels of PCT and IL-6 of the two groups were higher than those at the previous time point,and the differences were statistically significant(P<0.05);at T_(1),there was no significant difference in PCT and IL-6 levels between the two groups;at T_(2) and T_(3),the levels of PCT and IL-6 in group B were higher than those in group A,the differences were statistically significant(P<0.05).There was no significant difference in infection rate between the two groups.Conclusion The ischemia-reperfusion injury of skeletal muscle can cause the increase of PCT and IL-6 levels,which can help to predict the severity and infection o

关 键 词：降钙素原 白细胞介素 骨骼肌 缺血再灌注 

分 类 号：R68[医药卫生—骨科学]