费森尤斯4008S血液透析机不同模式治疗尿毒症疗效及对血清炎性因子影响  

The Therapeutic Effect of Different Modes of Fresenius 4008S Hemodialysis Machine on Uremia and Its Impact on Serum Inflammatory Factors

作　　者：郜翠翠 GAO Cui-cui(Tianjin Dongli Hospital,Tianjin 300300)

机构地区：[1]天津市东丽医院,天津300300

出　　处：《中国医疗器械信息》2024年第7期138-140,共3页China Medical Device Information

摘　　要：目的:研究费森尤斯4008S血液透析机不同模式治疗尿毒症疗效及对血清炎性因子影响。方法:将行血液透析治疗的72例尿毒症患者随机分为两组,观察组行高通量血液透析治疗,对照组行低通量血液透析治疗,观察两组临床疗效、治疗前后大分子毒素和血清炎性因子水平以及不良反应。结果:观察组治疗有效率显著高于对照组(P<0.05)。治疗后观察组血清瘦素、甲状旁腺激素、C反应蛋白、白细胞介素-6和肿瘤坏死因子α均显著低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:费森尤斯4008S血液透析机高通量血液透析治疗尿毒症可以更好清除大分子毒素,改善炎性因子,提升临床疗效,并且具有良好安全性。Objective:To study the therapeutic effect of different modes of the Fresenius 4008S hemodialysis machine on uremia and its impact on serum inflammatory factors.Methods:72 uremic patients who underwent hemodialysis treatment were randomly divided into two groups.The observation group received high flux hemodialysis treatment,while the control group received low flux hemodialysis treatment.The clinical efficacy,levels of macromolecular toxins and serum inflammatory factors before and after treatment,and adverse reactions were observed in both groups.Results:The effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the observation group had serum leptin,parathyroid hormone,C-reactive protein,interleukin-6,and tumor necrosis factorαall were significantly lower than the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The Fresenius 4008S hemodialysis machine with high flux hemodialysis can better remove macromolecular toxins,improve inflammatory factors,enhance clinical efficacy,and has good safety in the treatment of uremia.

关 键 词：费森尤斯4008S血液透析机 尿毒症 疗效 

分 类 号：R699.1[医药卫生—泌尿科学]