柏益前列康对非细菌性前列腺炎大鼠NF-кB信号通路的影响  

Effect of Baiyi Qianliekang Granules on NF-кB Signaling Pathway in Nonbacterial Prostatitis Rats

作　　者：刘小军 王珑 赵静 赵辉平 王俊琴 李雨容 LIU Xiaojun;WANG Long;ZHAO Jing;ZHAO Huiping;WANG Junqin;LI Yurong(Xi'an Xinrun Pharmaceutical Research and Development Center,Xi'an 710003,China.)

机构地区：[1]西安新润药业有限公司药物研发中心,西安710003

出　　处：《江西中医药大学学报》2024年第2期97-101,共5页Journal of Jiangxi University of Chinese Medicine

基　　金：陕西省重点研发计划项目(2022YWZX-03)。

摘　　要：目的:探讨柏益前列康颗粒(BQG)对角叉菜胶所致慢性非细菌性前列腺炎大鼠NF-κB信号通路的影响。方法:1%角叉菜胶复制慢性非细菌性前列腺炎大鼠模型,评估BQG对大鼠前列腺器官指数、组织病理形态以及大鼠前列腺组织中炎症因子IL-8、TNF-α及VEGF表达水平的影响,Western blot检测前列腺组织中NF-κB通路相关分子蛋白表达水平。结果:BQG可以降低前列腺器官指数,减轻前列腺组织内炎症反应。与模型组相比,BQG显著降低前列腺组织中炎症因子IL-8、TNF-α、VEGF表达水平及转录因子p-IκKα、p-IκBα、NF-κBP65、p-NF-κBP65蛋白表达水平(P<0.05)。结论:BQG可抑制角叉菜胶所致大鼠慢性非细菌性前列腺炎,其作用机制可能与抑制NF-кB信号通路有关。Objective:To investigate the NF-кB signaling pathway in Baiyi Qianliekang granule(BQG)in nonbacterial prostatitis rats induced by carrageenan.Methods:Chronic nonbacterial prostatitis rat model was induced by 1%carrageenan.The effects of BQG on rat prostate organ index,histopathological morphology,as well as expression levels of inflammatory factors IL-8,TNF-α,VEGF in rat prostate tissue were evaluated.Western blot was used to detect the expression of NF-κB pathway-related molecular proteins in rat prostate tissues.Results:BQG could reduce prostate organ index and reduces inflammation in prostate tissue.Compared with the model group,the expression levels of inflammatory factors IL-8,TNF-α,VEGF and the expression levels of transcription factors p-IκBα,p-IκKα,NF-κBP65,p-NF-κBP65 in prostate tissue were significantly decreased(P<0.05).Conclusion:BQG can inhibit chronic nonbacterial prostatitis rats induced by carrageenan,and this effect may be related to inhibiting the activation of NF-кB signaling pathway.

关 键 词：柏益前列康颗粒 慢性非细菌性前列腺炎 炎症因子 NF-ΚB信号通路 

分 类 号：R285.5[医药卫生—中药学]