阿奇霉素序贯疗法联合红霉素治疗儿童肺炎支原体肺炎的临床效果分析  

Clinical Effect Analysis of Azithromycin Sequential Therapy Combined with Erythromycin in Treatment of Mycoplasmal Pneumoniae Pneumonia in Children

作　　者：刘毅坚[1] 周林[1] 秦建亚 Liu Yijian;Zhou Lin;Qin Jianya(Department of Pediatrics,Beijing Fengtai Hospital,Beijing 100071,China)

机构地区：[1]北京丰台医院儿科,北京100071

出　　处：《中国社区医师》2024年第7期35-37,共3页Chinese Community Doctors

摘　　要：目的:探讨阿奇霉素序贯疗法联合红霉素治疗儿童肺炎支原体肺炎的临床效果。方法:选取2017年2月—2023年2月北京丰台医院儿科收治的肺炎支原体肺炎患儿71例作为研究对象,采用随机数字表法分为观察组(n=36)和对照组(n=35)。两组均给予退热、平喘、止咳化痰、雾化吸入等对症治疗,对照组采用阿奇霉素序贯治疗,观察组在对照组基础上采用红霉素治疗。比较两组临床症状消失时间、住院时间及肺功能指标。结果:观察组发热、咳嗽、肺部啰音消失时间和住院时间短于对照组,差异有统计学意义(P<0.001)。治疗前,两组峰值呼气流速(PEF)、第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC比较,差异无统计学意义(P>0.05),治疗后,两组PEF、FEV_(1)、FVC、FEV_(1)/FVC高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:阿奇霉素序贯疗法联合红霉素治疗儿童肺炎支原体肺炎的临床效果显著,可以改善患儿肺功能,促进患儿康复,缩短患儿住院时间。Objective:To investigate the clinical effect of azithromycin sequential therapy combined with erythromycin in treatment of mycoplasmal pneumoniae pneumonia in children.Methods:A total of 71 children with mycoplasmal pneumoniae pneumonia admitted to the Department of Pediatrics of Beijing Fengtai Hospital from February 2017 to February 2023 were selected as the study subjects.They were divided into control group(n=35)and observation group(n=36)according to random number table method.Both groups were given symptomatic treatment such as antipyretic,antiasthma,cough and sputum relief,atomizing inhalation.The control group was treated with given azithromycin sequential therapy and the observation group was given erythromycin treatment on the basis of the control group.The disappearance time of clinical symptoms,length of hospital stay and lung function indexes were compared between the two groups.Results:The disappearance time of fever,cough and pulmonary rales as well as the length of hospital stay in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in peak expiratory flow rate(PEF),forced expiratory volume in 1 second(FEV_(1)),forced vital capacity(FVC)and FEV_(1)/FVC between the two groups(P>0.05);After treatment,PEF,FEV_(1),FVC and FEV_(1)/FVC in the two groups were higher than those before treatment,and these indexes in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Azithromycin sequential therapy combined with erythromycin has significant clinical effect in the treatment of mycoplasmal pneumoniae pneumonia in children,and can improve lung function,promote recovery,and shorten the length of hospital stay.

关 键 词：肺炎 支原体肺炎 阿奇霉素 红霉素 序贯疗法 肺功能 

分 类 号：R725.6[医药卫生—儿科]