肾康宁联合氯沙坦钾治疗高血压合并蛋白尿的效果观察  

Effect Observation of Shenkangning Combined with Losartan Potassium in Treatment of Hypertension Complicated with Proteinuria

作　　者：田应芳 Tian Yingfang(Beijing Fengtai District Youanmen Community Health Service Center,Beijing 100069,China)

机构地区：[1]北京市丰台区右安门社区卫生服务中心,北京100069

出　　处：《中国社区医师》2024年第7期59-61,共3页Chinese Community Doctors

摘　　要：目的:观察肾康宁联合氯沙坦钾治疗高血压合并蛋白尿的效果。方法:选取2020年4月—2022年10月北京市丰台区右安门社区卫生服务中心收治的50例高血压合并蛋白尿患者作为研究对象,通过随机数字表法分为试验组和对照组,各25例。对照组给予氯沙坦钾治疗,试验组在对照组基础上给予肾康宁治疗。比较两组血肌酐(Scr)、尿微量白蛋白(mALB)、胱抑素C(Cys-C)、肾小球滤过率(eGFR)、血压水平,不良反应发生情况。结果:两组治疗前与对照组治疗前后Scr、Cys-C、mALB、eGFR水平比较,差异无统计学意义(P>0.05);治疗后,试验组Cys-C、mALB水平低于治疗前以及同期对照组,Scr、eGFR水平高于治疗前以及同期对照组,差异有统计学意义(P<0.05)。治疗前后,两组舒张压、收缩压水平比较,差异无统计学意义(P>0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:肾康宁联合氯沙坦钾治疗高血压合并蛋白尿的效果较好,能够改善患者肾功能,不良反应少。Objective:To observe the effect of Shenkangning combined with losartan potassium in the treatment of hypertension complicated with proteinuria.Methods:A total of 50 patients with hypertension and proteinuria who were admitted to Beijing Fengtai District Youanmen Community Health Service Center from April 2020 to October 2022 were selected as the study subjects.They were divided into the experimental group and the control group according to random number table method,with 25 cases in each group.The control group was treated with losartan potassium,and the experimental group was treated with Shenkangning on the basis of the control group.Serum creatinine(Scr),urine microalbumin(mALB),cystatin C(Cys-C),estimated glomerular filtration rate(eGFR),blood pressure levels,and the occurrence of adverse reactions were compared between the two groups.Results:There was no significant difference in the levels of Scr,Cys-C,mALB and eGFR between the two groups before treatment and in the control group before and after treatment(P>0.05);After treatment,the levels of Cys-C and mALB in the experimental group were lower than those before treatment and those in the control group during the same period,while the Scr,eGFR level in the experimental group was higher than that before treatment and that in the control group during the same period,and the difference was statistically significant(P<0.05).Before and after treatment,there was no significant difference in diastolic blood pressure and systolic blood pressure between the two groups(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Shenkangning combined with losartan potassium has a good effect in the treatment of hypertension complicated with proteinuria,which can improve the renal function of patients with few adverse reactions.

关 键 词：高血压 蛋白尿 肾康宁 氯沙坦钾 

分 类 号：R544.1[医药卫生—心血管疾病]