慢性阻塞性肺病急性发作期患者血栓弹力图参数与凝血功能的相关性分析  

Application of Correlation Between Thromboelastogram Parameters and Coagulation Function in Patients with Acute Attack of Chronic Obstructive Pulmonary Disease

作　　者：王道伟[1] 孙文[1] 李德勇[1] 毛占存 刘建[1] 金龙[1] 高永河[1] Wang Daowei;Sun Wen;Li Deyong;Mao Zhancun;Liu Jian;Jin Long;Gao Yonghe(Department of Critical Care Medicine,Jurong Peoples Hospital,Jurong 212400,Jiangsu Province,China)

机构地区：[1]句容市人民医院重症医学科,江苏句容212400

出　　处：《中国社区医师》2024年第7期92-94,共3页Chinese Community Doctors

基　　金：2020年句容市民生科技计划项目(编号:2020SA00121)。

摘　　要：目的:探讨慢性阻塞性肺病(COPD)急性发作期患者血栓弹力图参数与凝血功能的相关性。方法:选取2019年1月—2021年6月句容市人民医院收治的120例COPD患者作为观察组,选择同期体检健康者60例作为对照组。两组受检者均进行血栓弹力图检测与凝血功能检测。观察组给予常规治疗,比较两组以及观察组治疗前后血栓弹力图参数、凝血功能指标,分析COPD急性发作期患者血栓弹力图参数与凝血功能指标的相关性。结果:观察组凝血反应时间、凝固时间短于对照组,Angle角、最大振幅大于对照组,差异有统计学意义(P<0.001)。观察组D-二聚体(D-D)、纤维蛋白原(FIB)水平高于对照组,凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)短于对照组,差异有统计学意义(P<0.001)。COPD急性发作期患者凝血反应时间、凝固时间与D-D、FIB呈负相关,与TT、PT、APTT呈正相关;Angle角、最大振幅与D-D、FIB呈正相关,与TT、PT、APTT呈负相关(P<0.05)。治疗后,观察组凝血反应时间、凝固时间、TT、PT、APTT长于治疗前,Angle角、最大振幅小于治疗前,D-D、FIB水平低于治疗前,差异有统计学意义(P<0.001)。结论:COPD急性加重期患者血栓弹力图参数与凝血功能指标具有相关性,并能辅助评估治疗效果。Objective:To explore the correlation between thromboelastogram parameters and coagulation function in patients with acute attack of chronic obstructive pulmonary disease(COPD).Methods:A total of 120 patients with COPD treated in Jurong Peoples Hospital from January 2019 to June 2021 were selected as the observation group,and 60 health examination subjects during the same time period were selected as the control group.Thromboelastography and coagulation function testing were performed in both groups of subjects.The observation group was given conventional treatment.The thromboelastogram parameters and coagulation function indexes were compared between the two groups and in the observation group before and after treatment.The correlation between thromboelastogram parameters and coagulation function indexes in patients with acute attack of COPD was analyzed.Results:The coagulation reaction time and coagulation time in the observation group were shorter than those in the control group,and the angle and maximum amplitude in the observation group were greater than those in the control group,and the difference was statistically significant(P<0.001).The levels of D-dimer(D-D)and fibrinogen(FIB)in the observation group were higher than those in the control group,and the thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.001).In patients with acute attack of COPD,the coagulation reaction time and coagulation time were negatively correlated with D-D and FIB,and positively correlated with TT,PT and APTT;the angle and maximum amplitude were positively correlated with D-D and FIB,and negatively correlated with TT,PT and APTT(P<0.05).After treatment,the coagulation reaction time,coagulation time,TT,PT and APTT in the observation group were longer than those before treatment,the angle and maximum amplitude in the observation group were lower than those before treatment,and t

关 键 词：慢性阻塞性肺疾病急性发作期 凝血功能 血栓弹力图 

分 类 号：R447[医药卫生—诊断学]