高频振荡通气联合一氧化氮吸入对早产儿持续肺动脉高压疗效以及氧合指数的影响  

Effect of High Frequency Oscillatory Ventilation Combined with Nitric Oxide Inhalation on the Efficacy and Oxygenation Index of Premature Infants with Persistent Pulmonary Hypertension

作　　者：吴淑媛 聂红琴 鲁雪平 Wu Shuyuan(Jiujiang maternal and child health hospital,Jiujiang Jiangxi 332000)

机构地区：[1]九江市妇幼保健院新生儿科,江西九江332000 [2]九江市妇幼保健院眼科,江西九江332000

出　　处：《黑龙江医药》2024年第2期276-279,共4页Heilongjiang Medicine journal

基　　金：九江市科技计划项目(编号:S2022ZDYFN263)。

摘　　要：目的:探究高频振荡通气联合一氧化氮吸入在早产儿持续肺动脉高压中的应用效果。方法:按随机数字表法将2022年8月至2023年10月我院新生儿重症监护室(NICU)收治的持续肺动脉高压早产儿分为对照组(30例),观察组(30例)。对照组采用高频振荡通气治疗,观察组加用一氧化氮吸入联合治疗,比较两组临床疗效、血气指标、肺动脉收缩压、机械通气时间、住院时间及并发症情况。结果:观察组总有效率(96.67%)高于对照组(73.33%),P<0.05;治疗后,观察组动脉血氧分压(PaO_(2))水平高于对照组,P<0.05;动脉血二氧化碳分压(PaCO_(2))、吸入氧浓度(FiO_(2))、氧合指数(OI)水平低于对照组,P<0.05;肺动脉收缩压(SPAP)水平低于对照组,P<0.05;经皮血氧饱和度(SpO_(2))水平高于对照组,P<0.05;观察组机械通气时间与住院时间均短于对照组,P<0.05;两组并发症发生率均较低。结论:高频振荡通气联合一氧化氮吸入在早产儿持续肺动脉高压中治疗效果确切,可有效改善患儿血气指标,促进通气,还可缩短住院时间,且并发症少,安全性较好,值得推广。Objective:To explore the application effect of high-frequency oscillatory ventilation combined with nitric oxide inhalation in premature infants with persistent pulmonary hypertension.Methods:according to the random number table method,premature infants with persistent pulmonary hypertension admitted to the neonatal intensive care unit(NICU)of our hospital from August 2022 to October 2023 were divided into the control group(30 cases)and the observation group(30 cases).The control group was treated with high-frequency oscillatory ventilation,and the observation group was additionally treated with nitric oxide inhalation.The clinical efficacy,blood gas indexes,pulmonary artery systolic pressure,mechanical ventilation time,hospitalization time and complications of the two groups were compared.Results:the total effective rate of the observation group(96.67%)was higher than that of the control group(73.33%),P<0.05;After treatment,the arterial partial pressure of oxygen(PaO_(2))of the observation group was higher than that of the control group,P<0.05;and the arterial partial pressure of carbon dioxide(PaCO_(2)),inspired oxygen concentration(FiO_(2)),and oxygenation index(OI)of the observation group were lower than those of the control group,P<0.05;The level of pulmonary artery systolic pressure(SPAP)was lower than that of the control group,P<0.05;and the level of percutaneous oxygen saturation(SpO_(2))was higher than that of the control group,P<0.05.The duration of mechanical ventilation and hospital stay in the observation group were shorter than those in the control group,P<0.05.The incidence of complications in both groups was low.Conclusion:high frequency oscillatory ventilation combined with nitric oxide inhalation in the treatment of premature infants with persistent pulmonary hypertension has exact effect,can effectively improve the blood gas indicators of children,promote ventilation,and can also shorten the length of hospital stay,with fewer complications and good safety,which is worthy of promotion.

关 键 词：早产儿持续肺动脉高压 高频振荡通气 一氧化氮 氧合指数 

分 类 号：R722.6[医药卫生—儿科]