胆碱能抗炎通路在急性肺损伤治疗中的研究进展  

Research Progress on the Cholinergic Anti-inflammatory Pathway in the Treatment of Acute Lung Injury

作　　者：隋华秀 李燕平 黄姗 米燕 俞燕萍 伊雪 SUI Huaxiu;LI Yanping;HUANG Shan;MI Yan;YU Yanping;YI Xue(Key laboratory of Functional and Clinical Translational Medicine of Fujian Province Universities,Xiamen Medical College,Xiamen 361023,China)

机构地区：[1]厦门医学院机能与临床转化福建省高校重点实验室,福建厦门361023

出　　处：《医学综述》2024年第10期1166-1170,共5页Medical Recapitulate

基　　金：福建省中青年教师教育科研项目(科技类)(JAT200720)。

摘　　要：急性肺损伤(ALI)可发展为急性呼吸窘迫综合征(ARDS),给临床带来严峻挑战,ALI的特征主要为剧烈的炎症反应以及较高的病死率。胆碱能抗炎通路(CAP)作为调节炎症反应的关键机制,通过迷走神经刺激、α7烟碱型乙酰胆碱受体激动剂以及乙酰胆碱酯酶抑制剂激活显著减少促炎性细胞因子的释放,减轻炎症和肺部损伤。目前关于CAP治疗ALI的研究已取得一定进展,未来深入研究CAP在临床治疗中的应用效果,可为ALI和ARDS患者提供更有效且安全的治疗选择。Acute lung injury(ALI)and its progression to acute respiratory distress syndrome(ARDS)present significant clinical challenges,characterized by severe inflammatory responses and high mortality rates.The cholinergic anti-inflammatory pathway(CAP),a key mechanism for regulating inflammatory responses,significantly reduces the release of pro-inflammatory cytokines,inflammation and lung injury through vagus nerve stimulation,activation ofα7 nicotinic acetylcholine receptors and acetylcholinesterase inhibitors.Recent research on the role of CAP in ALI treatment has shown promising progress.Future studies should further investigate the clinical application effect of CAP,aiming to provide more effective and safer treatment options for the patients with ALI and ARDS.

关 键 词：急性肺损伤 胆碱能抗炎通路 急性呼吸窘迫综合征 

分 类 号：R563.9[医药卫生—呼吸系统]