p53基因在肝癌发展过程中的研究进展  

Research Progress of p53 Gene in Development of Liver Cancer

作　　者：杨光[1] 蒋新卫[2] YANG Guang;JIANG Xinwei(Gusu School,Nanjing Medical University,Suzhou 215000,China;Department of Hepatobiliary Surgery,the Affiliated Suzhou Hospital of Nanjing Medical University/Suzou Municipal Hospital,Suzhou 215000,China)

机构地区：[1]南京医科大学姑苏学院,江苏苏州215000 [2]南京医科大学附属苏州医院苏州市立医院肝胆外科,江苏苏州215000

出　　处：《医学综述》2024年第10期1200-1204,1210,共6页Medical Recapitulate

基　　金：苏州市肝胆外科临床医学中心项目(Szlcyxzxj202107)。

摘　　要：p53是一种重要的人类肿瘤抑制基因,许多肿瘤伴有p53基因突变。肝癌是常见的恶性肿瘤,也是癌症死亡的重要原因。在肝脏癌变过程中,许多癌基因被激活,同时抑癌基因失活。p53基因失活在肝癌的发展过程中起重要作用,但具体的作用机制目前尚未明确。p53可调控细胞周期和凋亡、参与细胞代谢和细胞自噬、促进肝癌侵袭及转移。因此,深入研究p53基因在肝癌中的作用机制,可以为疾病的治疗提供新思路。p53 is an important human tumor suppressor gene,and many tumors are accompanied by mutations of the p53 gene.Liver cancer is a common malignant tumor and an important cause of cancer death.During liver carcinogenesis,a lot of oncogenes are activated while suppressor genes are inactivated.p53 gene inactivation plays an important role in the development of liver cancer,although the specific mechanism of its action has not yet been clarified.p53 regulates cell cycle and apoptosis,participates in cell metabolism and cell autophagy,and promotes invasion and metastasis of liver cancer.Therefore,in-depth studies of the mechanism of p53 gene in liver cancer can provide new ideas for the treatment of the disease.

关 键 词：肝癌 P53 细胞周期 细胞凋亡 细胞代谢 侵袭及转移 细胞自噬 

分 类 号：R757.7[医药卫生—皮肤病学与性病学]