聚偏氟乙烯纳米纤维的结构调控及其在生物医学领域应用研究进展  

Structural regulation and biomedical applications of polyvinylidene fluoride nanofibers

作　　者：李朝威 成悦 苏新 陈鹏飞 李大伟 付译鋆 LI Chaowei;CHENG Yue;SU Xin;CHEN Pengfei;LI Dawei;FU Yijun(College of Textile and Clothing,Nantong University,Nantong,Jiangsu 226019,China;National&Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Health,Nantong University,Nantong,Jiangsu 226019,China)

机构地区：[1]南通大学纺织服装学院,江苏南通226019 [2]南通大学安全防护用特种纤维复合材料研发国家地方联合工程研究中心,江苏南通226019

出　　处：《纺织学报》2024年第4期229-237,共9页Journal of Textile Research

基　　金：南通市科技计划项目(MS22022068);南通大学大学生创新训练计划项目(2023149)。

摘　　要：为促进聚偏氟乙烯(PVDF)基纳米纤维在生物医学领域的应用,首先阐述了PVDF压电效应产生的关键在于其偶极子的取向排列,进一步以PVDF纳米纤维为研究对象,分析了纳米纤维的偶极子与纤维表面极性电荷的键合作用机制;归纳总结了随机分布型、取向排列型、中空以及图案化PVDF纳米纤维的结构调控;重点讨论了石墨烯、氧化锌、钛酸钡以及碳纳米管等各种掺杂材料对静电纺PVDF复合纳米纤维薄膜压电性能的影响,并详细介绍了其在伤口敷料、药物载体以及组织工程等生物医学领域的应用。研究指出结构调控和添加剂掺杂以及2种方法的组合是提高PVDF压电性能的有效方法,有望进一步拓展PVDF基纳米复合压电材料在生物医学领域中的应用。Significance Polyvinylidene fluoride(PVDF)possess excellent electrical properties,which is currently one of the strongest piezoelectric polymers discovered.Among various preparation methods of PVDF piezoelectric nanofibers,PVDF nanofibers prepared by electrospinning have more advantages,including large specific surface area,high porosity,good biocompatibility and better piezoelectric property,etc.In addition,the structure of electrospun nanofibers is similar to that of extracellular matrix,which is beneficial for promoting cell proliferation and differentiation.At present,there have been numerous reports on the application of electrospun PVDF piezoelectric nanofibers in biomedical fields such as wound dressings,drug carriers,and tissue engineering,proving their enormous potential in biomedical applications.Progress In this paper,the piezoelectric characteristics of PVDF were analyzed.four types of electrospun PVDF nanofibers,consisting of random type,oriented type,hollow type,and patterned type were introduced and their process methods,structures,properties,and preparation principles were analyzed.The influence of the doping of fillers such as graphene,zinc oxide,barium carbonate,carbon nanotubes,etc and the creation of multi-layer composite structures on the structure and piezoelectric property of electrospun PVDF nanofibers were described.The results showed that these doped materials not only changed the original morphology of PVDF nanofibers,but also significantly improved their piezoelectric property.The multilayered composite structure nanofibers created by combining electrospinning PVDF fibers with nanofibers generated by another method(such as vapor phase polymerization,point spraying and extended flow method)exhibited higher voltage output.Because of outstanding biocompatibility and piezoelectricity,electrospun PVDF nanofibers are widely used in biomedical fields such as wound dressings,drug carriers and tissue engineering.It could be demonstrated that PVDF based piezoelectric scaffolds presented excellen

关 键 词：聚偏氟乙烯 纳米纤维 结构调控 压电特性 生物医用材料 

分 类 号：TS102.6[轻工技术与工程—纺织工程]