亮丙瑞林联合复方口服避孕药对EMT患者免疫功能及血清标志物的影响  

Effects of leuprorelin combined with oral contraceptive on immune function and serum markers in EMT patients

作　　者：伊婷 杨静[1] 陈海燕[1] 刘雁林[1] YI Ting;YANG Jing;CHEN Haiyan;LIU Yanlin(Department of Gynecology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学第五附属医院妇科,新疆乌鲁木齐830011

出　　处：《国际检验医学杂志》2024年第9期1054-1058,共5页International Journal of Laboratory Medicine

基　　金：新疆维吾尔自治区自然科学基金项目(2020D01C221)。

摘　　要：目的探究亮丙瑞林联合复方口服避孕药对子宫内膜异位症(EMT)患者免疫功能及血清标志物水平的影响。方法选择2021年1月至2023年1月在该院确诊并接受治疗的EMT患者109例,按照随机数字表法分为观察组(55例)和对照组(54例)。对照组给予腹腔镜手术联合孕三烯酮治疗,观察组在对照组基础上应用亮丙瑞林。比较两组患者治疗12周后的疗效及不良反应发生率;比较两组患者免疫功能相关指标[白细胞介素(IL)-1β、干扰素γ(IFN-γ)、IL-4、IL-10、T淋巴细胞(Th)1、Th2、Th1/Th2]、血清标志物[糖类抗原(CA)199、CA125、人附睾蛋白4(HE4)、抗子宫内膜抗体(EMAb)]、临床疗效及不良反应发生率。结果治疗3个月后,观察组患者临床效率为96.36%,显著高于对照组患者,差异有统计学意义(P<0.05);观察组患者不良反应发生率为9.09%,低于对照组患者,但差异无统计学意义(P>0.05);治疗3个月后,观察组患者外周血Th1/Th2显著高于对照组患者,血清IFN-γ、IL-4、外周血Th1及Th2显著低于对照组患者,差异有统计学意义(P<0.05);治疗3个月后,观察组患者血清CA199、CA125、HE4及EMAb水平均显著低于对照组患者,差异有统计学意义(P<0.05)。结论亮丙瑞林联合复方口服避孕药辅助腹腔镜术后EMT患者具有较好的临床疗效及药物安全性,同时能够显著改善患者Th1/Th2相关免疫功能水平、降低EMT相关血清标志物水平。Objective To explore the effects of leuprorelin combined with oral contraceptive on immune function and serum markers in patients with endometriosis(EMT).Methods A total of 109 patients with EMT diagnosed and treated in the hospital from January 2021 to January 2023 were divided into observation group(55 cases)and control group(54 cases)by random number table method.The control group was treated with laparoscopic surgery combined with gestrinone,and the observation group was treated with leuprorelin on the basis of the control group.The efficacy and incidence of adverse reactions were compared between the two groups after 12 weeks of treatment,and the related indexes of immune function[interleukin(IL)-1β,interferon-γ(IFN-γ),IL-4,IL-10,T lymphocytes(Th)1,Th2,Th1/Th2],serum markers[carbohydrate antigen(CA)199,CA125,human epididymal protein 4(HE4),anti endometrial antibody(EMAb)],clinical efficacy and incidence of adverse reactions were compared between the two groups.Results After 3 months of treatment,the clinical efficiency of patients in the observation group was 96.36%,which was higher than the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 9.09%,which was lower than that in the control group,but the difference was not statistically significant(P>0.05).After 3 months of treatment,the peripheral blood Th1/Th2 in the observation group was higher than that in the control group,while the levels of serum IFN-γ,IL-4,Th1 and Th2 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of serum CA199,CA125,HE4 and EMAb in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Leuprorelin combined with oral contraceptive has good clinical efficacy and drug safety in patients with EMT after laparoscopic operation.At the same time,it could signif

关 键 词：亮丙瑞林 子宫内膜异位症 免疫功能 血清标志物 

分 类 号：R711.71[医药卫生—妇产科学]