妊娠糖尿病孕妇血清SOX5和GLUT4表达水平与糖脂代谢和妊娠结局的关系  

Relationship between serum SOX5 and GLUT4 expression levels in pregnant women with gestational diabetes and glucose and lipid metabolism and pregnancy outcome

作　　者：房莹 龚丽云[1] 白利颖[1] FANG Ying;GONG Liyun;BAI Liying(Department of Obstetrics and Gynecology,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院妇产科,北京100020

出　　处：《国际检验医学杂志》2024年第9期1116-1120,1125,共6页International Journal of Laboratory Medicine

摘　　要：目的探讨SOX5、葡萄糖转运体4(GLUT4)在妊娠期糖尿病(GDM)患者血清中的表达水平及与妊娠结局的相关性。方法选取2021年1月至2023年3月该院收治的154例GDM妊娠期妇女作为GDM组,根据妊娠结局分为不良妊娠结局组(59例)和正常妊娠结局组(95例),选取同期在该院进行产检的健康妊娠期妇女150例作为对照组。收集一般资料,检测血清SOX5和GLUT4表达水平;采用Pearson相关性分析GDM组妊娠期妇女血清SOX5和GLUT4与胰岛素抵抗(IR)的关系,采用受试者工作特征(ROC)曲线评价SOX5和GLUT4表达水平对不良妊娠结局的预测价值,Logistic回归分析影响不良妊娠结局发生的因素。结果GDM组患者血清GLUT4表达水平[(2.47±0.51)μg/L]低于对照组[(5.33±1.59)μg/L],GDM组患者血清SOX5表达水平[(6.53±0.96)ng/mL]高于对照组[(1.76±0.34)ng/mL],差异均有统计学意义(P<0.05);与对照组比较,GDM组妊娠期妇女血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平均升高,高密度脂蛋白胆固醇(HDL-C)水平下降,差异有统计学意义(P<0.05);GDM组血清SOX5表达水平与TC、TG、LDL-C、FBG、FINS、HOMA-IR呈正相关,与HDL-C表达水平呈负相关,GLUT4表达水平与TC、TG、LDL-C、FBG、FINS、HOMA-IR呈负相关,与HDL-C表达水平呈正相关(均P<0.05);不良妊娠结局组患者血清GLUT4表达水平[(1.88±0.47)μg/L]低于正常妊娠结局组[(2.84±0.54)μg/L],不良妊娠结局组患者血清SOX5表达水平[(8.02±1.05)ng/mL]高于正常妊娠结局组[(5.61±0.91)ng/mL],差异有统计学意义(P<0.05);ROC曲线结果显示,血清SOX5和GLUT4表达水平预测GDM患者不良妊娠结局的曲线下面积(AUC)分别为0.871(95%CI:0.807~0.919)、0.884(95%CI:0.822~0.930),对应的灵敏度分别为88.14%、74.58%,特异度分别为74.74%、88.42%,二者联合预测的AUC为0.940(95%CI:0.889~0.972),灵敏度为74.58%,特异度为96.84Objective To investigate the expression of SOX5 and glucose transporter 4(GLUT4)in the serum of women with gestational diabetes mellitus(GDM)and their correlation with pregnancy outcome.Methods A total of 154 pregnant women with GDM admitted to the hospital from January 2021 to March 2023 were collected as the GDM group,according to pregnancy outcomes,they were grouped into the adverse pregnancy outcome group(59 cases)and the normal pregnancy outcome group(95 cases),during the same period,150 healthy pregnant women who underwent prenatal examinations in the hospital were collected as the control group.General information was collected and the expression levels of serum SOX5 and GLUT4 were detected.Pearson correlation was applied to analyze the relationship between serum SOX5 and GLUT4 levels and insulin resistance(IR)in pregnant women with GDM,and receiver operating characteristic(ROC)curve was applied to evaluate the predictive value of SOX5 and GLUT4 levels for adverse pregnancy outcomes.Logistic regression was applied to analyze the factors that affect the occurrence of adverse pregnancy outcomes.Results The serum GLUT4 level in the GDM group[(2.47±0.51)μg/L]was lower than that in the control group[(5.33±1.59)μg/L],the serum SOX5 level in the GDM group[(6.53±0.96)ng/mL]was higher than that in the control group[(1.76±0.34)ng/mL],and the differences were statistically significant(P<0.05).Compared with the control group,the levels of total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),fasting insulin(FINS),and insulin resistance index(HOMA-IR)all increased,while high-density lipoprotein cholesterol(HDL-C)level decreased,and the differences were statistically significant(P<0.05).The expression level of SOX5 in serum of GDM group was positively correlated with TC,TG,LDL-C,FBG,FINS,HOMA-IR,and negatively correlated with the expression level of HDL-C,the expression level of GLUT4 was negatively correlated with TC,TG,LDL-C,FBG,FINS,HOMA-IR,and positively

关 键 词：妊娠期糖尿病 葡萄糖转运体4 SOX5 妊娠结局 

分 类 号：R714[医药卫生—妇产科学] R446.11[医药卫生—临床医学]