甲状腺功能减退相关性肌酸激酶升高的研究进展  

Research progress of hypothyroidism related creatine kinase elevation

作　　者：王渭鉴(综述) 陈慧(审校)[1] WANG Weijian;CHEN Hui(Department of Endocrinology and Metabolism,the Second Hospital of Lanzhou University,Lanzhou,Gansu 730030,China)

机构地区：[1]兰州大学第二医院内分泌代谢科,甘肃兰州730030

出　　处：《国际检验医学杂志》2024年第9期1141-1144,1152,共5页International Journal of Laboratory Medicine

基　　金：甘肃省科技厅自然科学基金项目(21R7RA416);甘肃省兰州大学第二医院“萃英科技创新计划”项目(CY2018-ZD02)。

摘　　要：甲状腺功能减退症(简称甲减)是内分泌系统常见的疾病。甲减可继发血清肌酸激酶(CK)升高,发病机制涉及骨骼肌和心肌损伤。患者早期多表现为无症状或轻症状高肌酸激酶血症,进而可发展为甲减性肌病(HM)和(或)甲减性心脏病。甲减相关性CK升高起病隐匿,若不及时治疗,可引发横纹肌溶解、冠心病、心力衰竭等严重并发症。大多数患者经左甲状腺素替代治疗后效果显著,CK随甲状腺功能的改善而恢复正常。Hypothyroidism is a common disorder of the endocrine systerm.Hypothyroidism can lead to secondary elevation of serum creatine kinase(CK),and its pathogenesis involves skeletal and cardiac injury.Patients often present with asymptomatic or mild symptoms of hypercreatine kinase in the early stages,which can progress to hypothyroid myopathy(HM)and(or)hypothyroidism heart disease.Hypothyroidism related CK elevation has an insidious onset,and if left untreated,it could lead to serious complications,such as rhabdommyolysis,coronary heart disease,heart failure,and so o n.Most patients show significant effects after receiving left thyroxine replacement therapy,and CK returns to normal with the improvement of thyroid function.

关 键 词：甲状腺功能减退 肌酸激酶 甲状腺激素 骨骼肌 心肌 

分 类 号：R581.2[医药卫生—内分泌]