小口径人工血管的研究现状及展望  

Research Progress and Prospect of Small-Caliber Artificial Blood Vessels

作　　者：吴鑫[1] 侯磊 许锋 WU Xin;HOU Lei;XU Feng(Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry,Guangxi Key Laboratory of Regenerative Medicine,Guangxi Medical University,Nanning 530021,China;Department of Cardiology,Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 201600,China;Department of Discipline Planing,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心,广西再生医学重点实验室,南宁530021 [2]上海交通大学医学院附属松江医院心内科,上海201600 [3]上海交通大学医学院附属第九人民医院学科规划处,上海200011

出　　处：《医用生物力学》2024年第2期355-360,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(82270276);公立医疗机构科技成果协同转化规范化体系(23ZC2520200);上海交通大学“交大之星”计划“医工交叉研究基金”(YG2019ZDA19)。

摘　　要：近年来,由于心血管疾病发生率逐渐上升,临床上对再生血管的需求日益增加。目前,大口径人工血管(直径>6 mm)已成功应用于临床,小口径人工血管(直径<6 mm)由于血栓形成、内膜增生、炎症反应和顺应性差导致血流动力学改变等原因,使其移植后远期通畅率低,距离临床应用尚有一段距离。其中,快速内皮化、抑制血栓形成及与自体血管相匹配的顺应性仍是解决问题的关键。本文简述制备小口径人工血管常用材料及技术的特点,重点讨论提高人工血管生物相容性和顺应性的策略,并对未来的研究工作进行展望。In recent years,the incidence of cardiovascular diseases has been gradually increasing,leading to a growing demand for regenerative blood vessels in clinic.Currently,large-caliber artificial blood vessels(diameter>6 mm)have been successfully applied in clinical practice.However,small-caliber artificial blood vessels(diameter<6 mm)still face challenges in long-term patency rates after transplantation due to thrombosis,intimal hyperplasia,inflammatory reactions,and poor compliance which leads to hemodynamic changes.Achieving rapid endothelialization,inhibiting thrombus formation,and matching the compliance of autologous vessels remain key factors to be addressed.This article provides a brief overview of commonly used materials and techniques for preparing small-caliber artificial blood vessels,with a focus on discussing strategies to improve biocompatibility and compliance.Furthermore,future research work is also prospected.

关 键 词：小口径人工血管 生物相容性 内皮化 顺应性 

分 类 号：R318.01[医药卫生—生物医学工程]