Classificatory updates in verrucous and cuniculatum carcinomas:Insights from the 5^(th) edition of WHO-IARC head and neck tumor classification  

作　　者：Felipe Martins Silveira Lauren Frenzel Schuch Ronell Bologna-Molina 

机构地区：[1]Department of Diagnostics in Oral Pathology and Oral Medicine,Faculty of Dentistry,Universidad de la República,Montevideo 1600,Uruguay [2]Department of Oral Pathology,Universidad Juarez del Estado de Durango,Durango 13400,Mexico

出　　处：《World Journal of Clinical Oncology》2024年第4期464-467,共4页世界临床肿瘤学杂志（英文版）

摘　　要：The International Agency for Research on Cancer(IARC)and World Health Organization(WHO)collaboratively produce the'WHO Blue Books'essential tools standardizing the diagnostic process for human cancers.Regular updates in this classification accommodate emerging molecular discoveries,advances in immunohistochemical techniques,and evolving clinical insights.The 5th edition of the WHO/IARC classification of head and neck tumors refines the'Oral Cavity and Mobile Tongue'chapter,including sections for non-neoplastic lesions,epithelial tumors,and tumors of uncertain histogenesis.Notably,the epithelial tumors section is rearranged by tumor behavior,starting with benign squamous papillomas and progressing through potentially malignant oral disorders to oral squamous cell carcinoma(OSCC).The section on OSCC reflects recent information on epidemiology,pathogenesis,and histological prognostic factors.Noteworthy is the specific categorization of verrucous carcinoma(VC)and carcinoma cuniculatum(CC),both associated with the oral cavity and distinct in clinical and histologic characteristics.This classification adjustment emphasizes the oral cavity as their predominant site in the head and neck.Designating specific sections for VC and CC aims to provide comprehensive insights into these unique subtypes,elucidating their clinical features,distinct histological characteristics,prevalence,significance,and clinical relevance.By categorizing these subtypes into specific sections,the 5th edition of the WHO classification aims to provide a more nuanced and detailed account,enhancing our understanding of these specific variants within the broader spectrum of head and neck tumors.

关 键 词：World Health Organization Squamous cell carcinoma of head and neck Verrucous carcinoma Mouth neoplasms 

分 类 号：R739.91[医药卫生—肿瘤]