Challenges and pitfalls of youth-onset type 2 diabetes  

作　　者：Lavinia La Grasta Sabolic Sanda Marusic Maja Cigrovski Berkovic 

机构地区：[1]Department of Pediatric Endocrinology and Diabetology,University Hospital Centre Sestre Milosrdnice,Zagreb 10000,Croatia [2]School of Medicine,Catholic University of Croatia,Zagreb 10000,Croatia [3]Department for Sport and Exercise Medicine,University of Zagreb Faculty of Kinesiology,Zagreb 10000,Croatia

出　　处：《World Journal of Diabetes》2024年第5期876-885,共10页世界糖尿病杂志（英文版）（电子版）

摘　　要：The incidence and prevalence of youth-onset type 2 diabetes mellitus(T2DM)are increasing.The rise in frequency and severity of childhood obesity,inclination to sedentary lifestyle,and epigenetic risks related to prenatal hyperglycemia exposure are important drivers of the youth-onset T2DM epidemic and might as well be responsible for the early onset of diabetes complications.Indeed,youth-onset T2DM has a more extreme metabolic phenotype than adult-onset T2DM,with greater insulin resistance and more rapid deterioration of beta cell function.Therefore,intermediate complications such as microalbuminuria develop in late childhood or early adulthood,while end-stage complications develop in mid-life.Due to the lack of efficacy and safety data,several drugs available for the treatment of adults with T2DM have not been approved in youth,reducing the pharmacological treatment options.In this mini review,we will try to address the present challenges and pitfalls related to youth-onset T2DM and summarize the available interventions to mitigate the risk of microvascular and macrovascular complications.

关 键 词：Youth-onset type 2 diabetes mellitus Insulin resistance Beta cell failure Risk factors Therapy COMPLICATIONS 

分 类 号：R587.1[医药卫生—内分泌]