Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers  

作　　者：Xue-Qin Wang Dan-Lan Pu Wei-Ling Leng Xiao-Tian Lei Jiang Juan Zou La Ding Yao Jia-Zhuang Xi Li Jian Teng Miao Qi-Nan Wu 

机构地区：[1]Endocrinology Department,The People’s Hospital of Yubei District of Chongqing City,Chongqing 401120,China [2]Department of Endocrinology,Chongqing Yubei District People’s Hospital,Chongqing 400030,China [3]Endocrinology Department,The First Affiliated Hospital of the Army Medical University,Chongqing 400038,China [4]Endocrinology and Nephrology Department,Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital,Chongqing 400016,China [5]Department of Endocrinology,Dazu Hospital of Chongqing Medical University,The People’s Hospital of Dazu,Chongqing 402360,China

出　　处：《World Journal of Diabetes》2024年第5期923-934,共12页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the Chongqing Science and Technology Bureau and Health Commission of Chinese Medicine Technology Innovation and Application Development Project,No.2020ZY013540;General Project of Chongqing Natural Science Foundation,No.CSTB2023NSCQMSX0246 and No.CSTB2022NSCQ-MSX1271;Science and Health Joint Project of Dazu District Science and Technology Bureau,No.DZKJ2022JSYJ1001.

摘　　要：BACKGROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability,traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment method.AIM To investigate whether Huangma Ding or autologous platelet-rich gel(APG)treatment would benefit diabetic lower extremity arterial disease(LEAD)patients with foot ulcers.METHODS A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups:Group A(62 patients;basal treatment),Group B(38 patients;basal treatment and APG),and Group C(55 patients;basal treatment and Huangma Ding).All patients underwent routine follow-up visits for six months.After follow-up,we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between parameters.RESULTS The infection status of the three groups before treatment was the same.Procalcitonin(PCT)improved after APG and Huangma Ding treatment more than after traditional treatment and was significantly greater in Group C than in Group B.Logistic regression analysis revealed that PCT was positively correlated with total amputation,primary amputation,and minor amputation rates.The ankle-brachial pressure and the transcutaneous oxygen pressure in Groups B and C were greater than those in Group A.The major amputation rate,minor amputation rate,and total amputation times in Groups B and C were lower than those in Group A.CONCLUSION Our research indicated that diabetic foot ulcers(DFUs)lead to major amputation,minor amputation,and total amputation through local infection and poor microcirculation and macrocirculation.Huangma Ding and APG were effective attreating DFUs.The clinical efficacy of Huangma Ding was better than that of autologous platelet gel,which may be related to the better control of local infection by Huangma Ding.This finding suggested that in patients with DFUs combined with coinfection,controlling infection is as important as improving circu

关 键 词：Diabetic foot ulcer Huangma Ding Autologous platelet-rich gel Ankle-brachial index Transcutaneous oxygen partial pressure 

分 类 号：R587.2[医药卫生—内分泌]