Long-term assessment of collagenase treatment for Dupuytren’s contracture:A 10-year follow-up study  

作　　者：Marco Passiatore Vitale Cilli Adriano Cannella Ludovico Caruso Giulia Maria Sassara Giuseppe Taccardo Rocco De Vitis 

机构地区：[1]Department of Bone and Joint Surgery,ASST-Spedali Civili,Brescia 25123,Italy [2]Department of Chirurgie de la Main,Centre Hospitalier Interregional Edith Cavell,Bruxelles 1160,Belgium [3]Department of Orthopedics,Fondazione Policlinico Universitario Agostino Gemelli IRCSS,Rome 00168,Italy

出　　处：《World Journal of Orthopedics》2024年第4期355-362,共8页世界骨科杂志（英文版）

摘　　要：BACKGROUND Enzymatic fasciotomy with collagenase clostridium histolyticum(CCH)has revolutionized the treatment for Dupuytren’s contracture(DC).Despite its benefits,the long-term outcomes remain unclear.This study presented a comprehensive 10-year follow-up assessment of the enduring effects of CCH on patients with DC.AIM To compare the short-term(12 wk)and long-term(10 years)outcomes on CCH treatment in patients with DC.METHODS A cohort of 45 patients was treated with CCH at the metacarpophalangeal(MCP)joint and the proximal interphalangeal(PIP)joint and underwent systematic reevaluation.The study adhered to multicenter trial protocols,and assessments were conducted at 12 wk,7 years,and 10 years post-surgery.RESULTS Thirty-seven patients completed the 10-year follow-up.At 10 years,patients treated at the PIP joint exhibited a 100%recurrence.However,patients treated at the MCP joint only showed a 50%recurrence.Patient satisfaction varied,with a lower satisfaction reported in PIP joint cases.Recurrence exceeding 20 degrees on the total passive extension deficit was observed,indicating a challenge for sustained efficacy.Significant differences were noted between outcomes at the 7-year and 10-year intervals.CONCLUSION CCH demonstrated sustained efficacy when applied to the MCP joint.However,caution is warranted for CCH treatment at the PIP joint due to a high level of recurrence and low patient satisfaction.Re-intervention is needed within a decade of treatment.

关 键 词：COLLAGENASE Xiapex Dupuytren disease Dupuytren recurrence Long term follow-up 

分 类 号：R318.08[医药卫生—生物医学工程]