Systemic immune-inflammation index,neutrophilto-lymphocyte ratio,and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy  

作　　者：Ying Gao Rong-Xin Lu Yun Tang Xin-Yi Yang Hu Meng Chang-Lin Zhao Yi-Lu Chen Feng Yan Qian Cao 

机构地区：[1]Department of Ophthalmology,Sir Run Run Hospital,Nanjing Medical University,Nanjing 211112,Jiangsu Province,China [2]Department of Ophthalmology,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,Jiangsu Province,China [3]Department of Thoracic Surgery,the First Affiliated Hospital with Nanjing Medical University,Nanjing 210029,Jiangsu Province,China [4]Medical School,Nanjing University,Nanjing 210093,Jiangsu Province,China [5]Department of Ophthalmology,Taikang Xianlin Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210046,Jiangsu Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第5期877-882,共6页国际眼科杂志（英文版）

基　　金：Affiliated Jinling Hospital,Medical School of Nanjing University(No.22JCYYYB29).

摘　　要：AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were calculated.The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)curves.The relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic regression.RESULTS:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(P<0.001 for all);and higher in the PDR group than in the NDR group(P<0.001 for all).In the ROC curve analysis,the NLR,PLR,and SII were significant predictors of DR(P<0.001 for all).The highest area under the curve(AUC)was for the PLR(0.929 for PLR,0.925 for SII,and 0.821 for NLR).Multivariate regression analysis indicated that NLR,PLR,and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM[odds ratio(OR)=1.122,95%confidence interval(CI):0.200–2.043,P<0.05;OR=0.038,95%CI:0.018–0.058,P<0.05;OR=0.007,95%CI:0.001–0.01,P<0.05,respectively).CONCLUSION:The NLR,PLR,and SII may be used as predictors of DR.

关 键 词：diabetic retinopathy neutrophil-tolymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]